Harnessing systems biology approaches to engineer functional microvascular networks.

Tissue Engineering. Part B, Reviews
Lauren S SefcikEdward A Botchwey

Abstract

Microvascular remodeling is a complex process that includes many cell types and molecular signals. Despite a continued growth in the understanding of signaling pathways involved in the formation and maturation of new blood vessels, approximately half of all compounds entering clinical trials will fail, resulting in the loss of much time, money, and resources. Most pro-angiogenic clinical trials to date have focused on increasing neovascularization via the delivery of a single growth factor or gene. Alternatively, a focus on the concerted regulation of whole networks of genes may lead to greater insight into the underlying physiology since the coordinated response is greater than the sum of its parts. Systems biology offers a comprehensive network view of the processes of angiogenesis and arteriogenesis that might enable the prediction of drug targets and whether or not activation of the targets elicits the desired outcome. Systems biology integrates complex biological data from a variety of experimental sources (-omics) and analyzes how the interactions of the system components can give rise to the function and behavior of that system. This review focuses on how systems biology approaches have been applied to microvascular grow...Continue Reading

References

Jan 1, 1977·Bulletin of Mathematical Biology·L A LiottaJ Kleinerman
May 1, 1991·Journal of Biomechanical Engineering·L G CimaR Langer
Oct 7, 1991·Journal of Theoretical Biology·C L Stokes, D A Lauffenburger
Oct 1, 1990·Circulation Research·A R PriesJ F Gross
Jan 1, 1981·Microvascular Research·D F ZawickiS Chien
Nov 1, 1995·Circulation Research·A R PriesP Gaehtgens
Sep 18, 1998·Bulletin of Mathematical Biology·A R Anderson, M A Chaplain
Dec 10, 1998·Annals of Biomedical Engineering·A S PopelP J Tonellato
Apr 16, 1999·Mathematical Biosciences·M MarkusM Schmick
Apr 16, 1999·Science·L E NiklasonR Langer
Aug 19, 2000·Science·B St CroixK W Kinzler
Jun 5, 2001·Nature Reviews. Genetics·J Quackenbush
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Sep 25, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Andreas ZakrzewiczAxel R Pries
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junsuke IgarashiThomas Michel
Feb 10, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shayn M PeirceThomas C Skalak
Oct 8, 2004·Nature Biotechnology·Hans V Westerhoff, Bernhard O Palsson
Feb 11, 2005·Current Opinion in Chemical Biology·Rebecca A Butcher, Stuart L Schreiber
Feb 16, 2005·Bulletin of Mathematical Biology·Shuyu SunCharles W Patrick
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christian KorherrUlrich Brinkmann
Aug 8, 2006·Tissue Engineering·Kristen A WieghausEdward A Botchwey
Oct 14, 2006·Journal of Applied Physiology·Feilim Mac GabhannAleksander S Popel
Oct 19, 2006·Current Opinion in Biotechnology·Seth MichelsonChristina Friedrich
Dec 23, 2006·Nature Reviews. Cancer·Justin Lamb
Jan 5, 2007·Annals of Biomedical Engineering·Vijayakumar JanakiramanHarihara Baskaran
Mar 3, 2007·Nature Reviews. Drug Discovery·William LogingBryn Williams-Jones
Mar 3, 2007·Expert Review of Molecular Diagnostics·Vivek Mittal, Daniel J Nolan
Apr 17, 2007·Annals of Biomedical Engineering·Feilim Mac GabhannAleksander S Popel
Jun 6, 2007·British Journal of Pharmacology·S EkinsB Testa
Jun 15, 2007·Cancer Cell·Steven SeamanBrad St Croix
Jun 26, 2007·Tissue Engineering·Ehsan Jabbarzadeh, Cameron F Abrams
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amir AbdollahiPeter E Huber
Aug 29, 2007·Tissue Engineering·Kristen A WieghausEdward A Botchwey
Nov 22, 2007·Journal of Theoretical Biology·Katie BentleyPaul A Bates
Apr 12, 2008·The American Journal of Pathology·Rajendra BhatiNancy Klauber-DeMore
Jul 9, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Feilim Mac Gabhann, Aleksander S Popel
Aug 23, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Shayn M Peirce
Sep 20, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Axel R Pries, Timothy W Secomb
Sep 23, 2008·Biomaterials·Kristen A WieghausEdward A Botchwey

❮ Previous
Next ❯

Citations

Nov 4, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joshua K Meisner, Richard J Price
Mar 19, 2013·Biochimica Et Biophysica Acta·Michael KohlMartin Eisenacher

❮ Previous
Next ❯

Software Mentioned

Ingenuity Pathways Analysis
Connectivity Map

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved