Harnessing the Complete Repertoire of Conventional Dendritic Cell Functions for Cancer Immunotherapy

Pharmaceutics
Lukas AmonChristian H K Lehmann

Abstract

The onset of checkpoint inhibition revolutionized the treatment of cancer. However, studies from the last decade suggested that the sole enhancement of T cell functionality might not suffice to fight malignancies in all individuals. Dendritic cells (DCs) are not only part of the innate immune system, but also generals of adaptive immunity and they orchestrate the de novo induction of tolerogenic and immunogenic T cell responses. Thus, combinatorial approaches addressing DCs and T cells in parallel represent an attractive strategy to achieve higher response rates across patients. However, this requires profound knowledge about the dynamic interplay of DCs, T cells, other immune and tumor cells. Here, we summarize the DC subsets present in mice and men and highlight conserved and divergent characteristics between different subsets and species. Thereby, we supply a resource of the molecular players involved in key functional features of DCs ranging from their sentinel function, the translation of the sensed environment at the DC:T cell interface to the resulting specialized T cell effector modules, as well as the influence of the tumor microenvironment on the DC function. As of today, mostly monocyte derived dendritic cells (moDCs...Continue Reading

References

Feb 1, 1974·The Journal of Experimental Medicine·R M Steinman, Z A Cohn
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M C NussenzweigB Gutchinov
Aug 1, 1995·The Journal of Experimental Medicine·M F Krummel, J P Allison
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Mar 22, 1996·Science·D R LeachJ P Allison
Oct 1, 1996·Nature Medicine·C CondonL D Falo
Feb 3, 1997·The Journal of Experimental Medicine·P A van der MerweS J Davis
Jul 7, 1997·The Journal of Experimental Medicine·S R BennettW R Heath
Jun 10, 1998·The Journal of Experimental Medicine·K SaoulliT H Watts
Dec 8, 1998·The Journal of Experimental Medicine·C J KirschningM Rothe
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski

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Citations

Apr 14, 2021·Immunology Letters·Lukas HatscherDiana Dudziak
Jun 15, 2021·Journal of Immunology Research·Saghar PahlavanneshanMohsen Basiri

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Methods Mentioned

BETA
single cell sequencing
transfection
leukapheresis
glycosylation

Software Mentioned

STING
VISTA

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