Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine

Current Treatment Options in Cardiovascular Medicine
Arun SharmaSean M Wu

Abstract

Adult human cardiomyocytes are terminally differentiated and have limited capacity for cell division. Hence, they are not naturally replaced following ischemic injury to the heart. As such, cardiac function is often permanently compromised after an event such as myocardial infarction. In recent years, investigators have focused intensively on ways to reactivate cardiomyocyte mitotic activity in both in vitro cell culture systems and in vivo animal models. In parallel, advances in stem cell biology have allowed for the mass production of patient-specific human cardiomyocytes from human-induced pluripotent stem cells. These cells can be produced via chemically defined differentiation of human pluripotent stem cells in a matter of weeks and could theoretically be utilized directly for therapeutic purposes to replace damaged myocardium. However, stem cell-derived cardiomyocytes, like their adult counterparts, are post-mitotic and incapable of large-scale expansion after reaching a certain stage of in vitro differentiation. Due to this shared characteristic, these stem cell-derived cardiomyocytes may provide a platform for studying genes, pathways, and small molecules that induce cell cycle reentry and proliferation of human cardiom...Continue Reading

References

Feb 1, 1974·The Journal of Experimental Zoology·J O Oberpriller, J C Oberpriller
Aug 1, 1996·Journal of Molecular and Cellular Cardiology·F LiA M Gerdes
Dec 14, 2002·Science·Kenneth D PossMark T Keating
Jan 11, 2003·Circulation Research·Mimi Tamamori-AdachiMasa-Aki Ikeda
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
May 26, 2004·The Journal of Biological Chemistry·Hina W ChaudhryDebra J Wolgemuth
Jul 16, 2004·The Biochemical Journal·Katrina A BicknellGavin Brooks
May 5, 2005·The Journal of Biological Chemistry·Jooyoung JungYoungsook Lee
May 5, 2005·Genes & Development·Felix B EngelMark T Keating
Oct 26, 2005·Journal of Molecular and Cellular Cardiology·Todd C McDevittCharles E Murry
Sep 21, 2006·Chemistry & Biology·Ai-Sun TsengMark T Keating
Jan 26, 2008·Circulation Research·Heather J Evans-AndersonKatherine E Yutzey
Feb 12, 2008·Transplantation Proceedings·G M Abouna
Dec 10, 2008·Tissue Engineering. Part a·Kelly R StevensCharles E Murry
Jan 18, 2011·Nature·Ilanit ItzhakiLior Gepstein
Feb 26, 2011·Science·Enzo R PorrelloHesham A Sadek
Jul 23, 2011·Circulation Research·Enzo R PorrelloEric N Olson
May 31, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaojun LianSean P Palecek
Mar 7, 2013·Stem Cells and Development·Scott D LundyMichael A Laflamme
Feb 28, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tatyana NovoyatlevaFelix B Engel
Jun 16, 2014·Nature Methods·Paul W BurridgeJoseph C Wu
Oct 26, 2014·Cardiovascular Research·Francesca RochaisRobert G Kelly
Dec 6, 2014·Circulation Research·Caitlin C O'MearaRichard T Lee
Dec 18, 2014·Cell Stem Cell·Aitor AguirreJuan Carlos Izpisua Belmonte
Mar 20, 2015·Science Translational Medicine·Ying TianEdward E Morrisey

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Citations

Jan 30, 2018·Stem Cells International·Fabiana PassaroDomenico Bonaduce
Jan 6, 2018·Circulation Research·June-Wha Rhee, Joseph C Wu
Aug 3, 2018·Current Drug Targets·Paola LocatelliMariano Nicolás Belaich
Aug 25, 2016·Current Treatment Options in Cardiovascular Medicine·Vivekkumar PatelTodd K Rosengart
Jun 23, 2019·Current Cardiology Reports·Shin Kadota, Yuji Shiba
Sep 2, 2020·Journal of Pharmacological and Toxicological Methods·Christina SchmidGeorg Rast

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