Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders

Clinical Lipidology
Shyamalagauri Jadhav, Miriam L Greenberg

Abstract

The development of therapies for neuropsychiatric disorders is hampered by the lack of understanding of the mechanisms underlying their pathologies. While aberrant sphingolipid metabolism is associated with psychiatric illness, the role of sphingolipids in these disorders is not understood. The genetically tractable yeast model can be exploited in order to elucidate the cellular consequences of sphingolipid perturbation. Hypotheses generated from studies in yeast and tested in mammalian cells may contribute to our understanding of the role of sphingolipids in psychiatric disorders and to the development of new treatments. Here, we compare sphingolipid metabolism in yeast and mammalian cells, discuss studies implicating sphingolipids in psychiatric disorders and propose approaches that utilize yeast in order to elucidate sphingolipid function and identify drugs that target sphingolipid synthesis.

References

Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Feb 1, 1986·Archives of General Psychiatry·N AndreasenJ H Crossett
Jan 1, 1974·Acta Psychiatrica Scandinavica·D H Ingvar, G Franzén
Sep 15, 1974·Biochemical Pharmacology·C de DuveF Van Hoof
Jan 1, 1980·Archiv für Psychiatrie und Nervenkrankheiten·J S KimG Krzepinski
Jan 1, 1984·Annals of the New York Academy of Sciences·W T Norton
Dec 1, 1995·Archives of General Psychiatry·J W Olney, N B Farber
Sep 29, 1995·The Journal of Biological Chemistry·J K WestwickD A Brenner
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S Schulte, W Stoffel
Dec 20, 1993·Behavioural Brain Research·J E LeDoux
Dec 1, 1993·Journal of Neurochemistry·R ShinghalS M Bajjalieh
Nov 1, 1993·Biological Psychiatry·M NoponenJ Rotrosen
Mar 19, 1993·Science·L M ObeidY A Hannun
Jan 24, 1997·Cell·V E VelculescuK W Kinzler
Oct 23, 1997·The Journal of Biological Chemistry·J D SabaY A Hannun
Dec 31, 1997·The Journal of Biological Chemistry·R C DicksonR L Lester
Jan 24, 1998·The Journal of Biological Chemistry·G M JenkinsY Hannun
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TomiukW Stoffel
Jul 25, 1998·The Journal of Biological Chemistry·M M NagiecR C Dickson
Oct 6, 1998·Annual Review of Biochemistry·R C Dickson
Nov 7, 1998·The Journal of Biological Chemistry·S BasuR Kolesnick
Nov 21, 1998·The Journal of Biological Chemistry·A IshiiM Saito
Jun 15, 1999·Biochimica Et Biophysica Acta·R C Dickson, R L Lester
Apr 15, 2000·The Journal of Biological Chemistry·N ChungL M Obeid
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·K HofmannW Stoffel
Sep 23, 2000·Chemistry and Physics of Lipids·D Samet, Y Barenholz
Dec 2, 2000·Nature Biotechnology·B SchwikowskiS Fields

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemische Zeitschrift
H Wagner, W Zofcsik
Frontiers in Bioscience (Landmark Edition)
Sujatha Narayan, Elizabeth A Thomas
Current Opinion in Clinical Nutrition and Metabolic Care
Jonathan Shintaku, Denis C Guttridge
© 2022 Meta ULC. All rights reserved