Harnessing the properties of dendritic cells in the pursuit of immunological tolerance

Biomedical Journal
Christopher HortonPaul J Fairchild

Abstract

The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the "holy grail" of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases. Whilst various cell types exhibiting a tolerogenic phenotype have been proposed for such a task, tolerogenic dendritic cells (tol-DCs) are exquisitely adapted for antigen presentation and interact with many facets of the immune system: as such, they are attractive candidates for use in strategies for immune intervention. We review here our current understanding of tol-DC mediated induction and maintenance of immunological tolerance. Additionally, we discuss recent in vitro findings from animal models and clinical trials of tol-DC immunotherapy in the setting of transplantation, autoimmunity and allergy which...Continue Reading

Citations

Oct 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelia HilpertDavid Voehringer
Jun 5, 2019·Current Gene Therapy·Songjie Cai, Anil Chandraker
Feb 7, 2020·Journal of Cellular and Molecular Medicine·Chuan LiXiangchen Dai
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Methods Mentioned

BETA
transgenic
transfection
leukapheresis
genetic modification
blood draws
genetic modifications
biopsy

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