Abstract
The acquisition of self-perpetuating, immunological tolerance specific for graft alloantigens has long been described as the "holy grail" of clinical transplantation. By removing the need for life-long immunosuppression following engraftment, the adverse consequences of immunosuppressive regimens, including chronic infections and malignancy, may be avoided. Furthermore, autoimmune diseases and allergy are, by definition, driven by aberrant immunological responses to ordinarily innocuous antigens. The re-establishment of permanent tolerance towards instigating antigens may, therefore, provide a cure to these common diseases. Whilst various cell types exhibiting a tolerogenic phenotype have been proposed for such a task, tolerogenic dendritic cells (tol-DCs) are exquisitely adapted for antigen presentation and interact with many facets of the immune system: as such, they are attractive candidates for use in strategies for immune intervention. We review here our current understanding of tol-DC mediated induction and maintenance of immunological tolerance. Additionally, we discuss recent in vitro findings from animal models and clinical trials of tol-DC immunotherapy in the setting of transplantation, autoimmunity and allergy which...Continue Reading
Citations
Jan 24, 2018·Frontiers in Immunology·Patty SachamitrPaul J Fairchild
Feb 7, 2018·Frontiers in Immunology·Maxime De LaereNathalie Cools
Oct 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cornelia HilpertDavid Voehringer
Jun 5, 2019·Current Gene Therapy·Songjie Cai, Anil Chandraker
Feb 7, 2020·Journal of Cellular and Molecular Medicine·Chuan LiXiangchen Dai
May 2, 2020·Journal of Clinical Medicine·Alfrun SchönbergFelix Bock
Mar 15, 2018·Frontiers in Immunology·Hitoshi Hasegawa, Takuya Matsumoto
Jul 18, 2018·Frontiers in Immunology·Yue ZhaoGang Chen
Mar 16, 2019·Frontiers in Immunology·Willem van EdenFemke Broere
Apr 23, 2020·Frontiers in Immunology·Emanuelle de Souza SantosMilena Botelho Pereira Soares
Sep 19, 2020·Journal of Extracellular Vesicles·Mahmoud ElashiryChristopher W Cutler
Mar 10, 2018·Frontiers in Immunology·Eros MarínAurélie Moreau
May 16, 2018·Frontiers in Immunology·Inmaculada SerranoJosep M Aran
May 31, 2020·Inflammopharmacology·Kai ZhengJiangyi Yu
Mar 8, 2019·Cellular & Molecular Immunology·Michela ComiSilvia Gregori
May 31, 2018·Antibodies·Kathleen P Pratt
Nov 19, 2019·Frontiers in Immunology·Jitka FucikovaRadek Spisek
Aug 10, 2018·Yonsei Medical Journal·Sang Hyun KimChong Kil Lee
Jul 23, 2020·Frontiers in Immunology·Michela ComiSilvia Gregori
Feb 23, 2019·Frontiers in Immunology·Neda DjedovicÐorđe Miljković
Dec 16, 2019·Ageing Research Reviews·Antero Salminen
Sep 10, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Umut C KucuksezerCezmi A Akdis
Apr 4, 2021·Cells·Ze-Jun YangJing-Dong Xu
Mar 30, 2021·Frontiers in Immunology·Sara NessJohn R Gordon
May 1, 2021·Pharmaceutics·Tianqi WangJie Shen
Oct 12, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Maja MachcińskaGrażyna Korczak-Kowalska