Harnessing the therapeutic potential of extracellular vesicles for cancer treatment.

Seminars in Cancer Biology
Ying ZhangHang Yin

Abstract

Cancer therapeutic strategies include surgeries, radiotherapy, chemotherapy, targeted therapy and immunotherapies. However, current cancer treatment still faces challenges such as postoperative residuals, postoperative recurrence, chemoradiotherapy resistance and lack of drugs with high specificity, due to the complexity of the cancer environment. Extracellular vesicles (EVs) are lipid-capsuled membrane vesicles secreted from cells, communicating vital messages between cells and regarding function in tumorigenesis and metastasis. Investigation of compositions and functions of EVs may open unprecedented, promising avenues for cancer therapeutics. This review brings new perspectives from both researchers and clinicians in the EV field, emphasizing the ties between basic research and ongoing clinical trials. In sum, our review summarizes the roles EVs play in cancer therapy, ranging from mechanisms to applications in cancer treatment. In particular, it focuses on their therapeutic potential with an eye toward clinical relevance.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
Apr 18, 2001·Trends in Cell Biology·E J Brown, W A Frazier
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C ThéryS Amigorena
May 22, 2002·The Journal of Experimental Medicine·Giovanna AndreolaStefano Fais
Jul 31, 2002·Lancet·Fabrice AndreLaurence Zitvogel
Jul 19, 2003·Science·James C Carrington, Victor Ambros
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AndreL Zitvogel
Aug 27, 2005·Cell·Shveta BaggaAmy E Pasquinelli
Jun 9, 2006·European Journal of Immunology·Charlotte AdmyreSusanne Gabrielsson
Jan 2, 2007·Trends in Cell Biology·Ramesh S PillaiWitold Filipowicz
Sep 11, 2007·Immunology Letters·Monika Baj-KrzyworzekaMarek Zembala
Mar 1, 2008·Science·Katarina TrajkovicMikael Simons
Oct 15, 2008·PloS One·Venkateswara Rao SimhadriElke Pogge von Strandmann
Aug 20, 2009·Chemical Society Reviews·Annela M SeddonOscar Ces
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
May 4, 2010·Cellular Immunology·David KoosEwa Carrier
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
Dec 6, 2011·Annual Review of Immunology·Ralph M Steinman
Feb 9, 2012·Current Opinion in Immunology·Mark P ChaoRavindra Majeti
May 19, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiroshi Maeda
Aug 23, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arda MizrakOkay Saydam
Oct 4, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin-ichiro OhnoMasahiko Kuroda
Dec 20, 2012·Nature Communications·Ke TangBo Huang
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Sep 3, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sander A A KooijmansPieter Vader
Sep 7, 2013·Journal of Extracellular Vesicles·Kenneth W WitwerFred Hochberg

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