Has CXCL13 an added value in diagnosis of neurosyphilis?

Journal of Clinical Microbiology
Khutso M MothapoFoekje Stelma

Abstract

In patients with syphilis, central nervous system (CNS) involvement is often difficult to determine. In patients who also are infected with human immunodeficiency virus (HIV), this is even more challenging, as cerebrospinal fluid (CSF) pleocytosis can be attributed to HIV, syphilis, or both. Hence, this study investigated (i) CSF chemokine (C-X-C motif) ligand 13 (CXCL13) as a potential marker to diagnose neurosyphilis in HIV-infected individuals and (ii) the added value of CSF CXCL13 to conventional CSF biomarkers, such as the rapid plasma reagin test (RPR), in diagnosing neurosyphilis. We included 103 syphilis patients from two centers in The Netherlands: 47 non-HIV-infected patients and 56 HIV-infected patients. A positive CSF-RPR was regarded as the gold standard for neurosyphilis. CSF CXCL13 levels were significantly higher in neurosyphilis patients when neurosyphilis was diagnosed by CSF-RPR (P = 0.0002) than in the syphilis control group. The sensitivity and specificity of CSF CXCL13 (cutoff of 76.3 pg/ml) to diagnose neurosyphilis by using positive CSF-RPR as the gold standard were 50% and 90%, respectively. CSF CXCL13 had an added value to CSF-RPR positivity in 70% of HIV-positive patients and in 33% of HIV-negative pa...Continue Reading

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Citations

Aug 20, 2015·BMC Infectious Diseases·Susan Tuddenham, Khalil G Ghanem
Sep 21, 2016·Annales de dermatologie et de vénéréologie·D Guedes de CarvalhoO Carpentier
Oct 21, 2016·Journal of Neuroinflammation·Annukka PietikäinenJukka Hytönen
Jun 2, 2020·Expert Review of Anti-infective Therapy·Ilias MasourisUwe Ködel
Aug 6, 2020·International Journal of STD & AIDS·Sharon Chi, Amy Weintrob
Jul 30, 2019·Frontiers in Endocrinology·Marcelo G KazanietzMariana Cooke
Sep 15, 2016·Expert Review of Anti-infective Therapy·Chelsea P Roberts, Jeffrey D Klausner
Jan 14, 2021·Sexually Transmitted Infections·Dongdong LiChuanmin Tao
Dec 19, 2020·Open Medicine·Yan ZhangYongxing Yan
Jun 16, 2021·BMC Infectious Diseases·Gustavo Henrique Pereira BoogAnna S Levin

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