Has fine-needle aspiration biopsy changed thyroid practice?

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M HadiJ A Heerden

Abstract

To assess the influence of fine-needle aspiration (FNA) biopsy on the management of nodular thyroid disease. We retrospectively evaluated the effect of the availability of FNA biopsy on thyroid surgical practice at our institution by comparing the data for two study periods--1975-1976 (before the introduction of FNA) and 1985-1986 (5 years after its introduction). The study inclusion criteria were fulfilled by 1,451 patients. In 1975-1976, 938 patients had thyroid operations at our institution. FNA biopsy was introduced into our practice in 1980. In 1985-1986, 513 patients underwent a thyroid surgical procedure. Before the FNA era, the frequency of carcinoma in patients selected for thyroidectomy was 18%, whereas after FNA became available, it increased to 25% (P< 0.0001). When patients were selected for surgical treatment because of either "suspicious" or malignant cytologic results, the yield of carcinoma increased to 40%. These data suggest that FNA biopsy has improved selectivity for operation in patients with nodular thyroid disease and has reduced the number of patients who undergo thyroidectomy for benign disease. The result is an increasing yield of malignant lesions found at surgical intervention. FNA biopsy has had a ...Continue Reading

References

Jun 1, 1987·Southern Medical Journal·H J Baskin, L A Guarda
Nov 1, 1980·World Journal of Surgery·M A BlockS R Kini
Dec 1, 1995·The American Journal of Medicine·D Giuffrida, H Gharib
Feb 1, 1995·Journal of Endocrinological Investigation·A BelfioreO Ippolito
Jun 1, 1995·The Surgical Clinics of North America·K A Woeber
Feb 15, 1993·Annals of Internal Medicine·H Gharib, J R Goellner

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Citations

Jan 16, 1998·Endocrinology and Metabolism Clinics of North America·H Gharib
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Matthew C MillerEdmund A Pribitkin
Feb 7, 2012·Thyroid : Official Journal of the American Thyroid Association·Mio KitanoElectron Kebebew
Apr 15, 2008·World Journal of Surgery·Catharina Ihre LundgrenLambert Skoog
Dec 14, 2006·Advances in Surgery·Jennifer B OgilvieOrlo H Clark
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hossein Gharib
Feb 29, 2008·The Oncologist·Meei J Yeung, Jonathan W Serpell
Nov 5, 2004·Disease-a-month : DM·Usha Sriram, Lydia Marie Patacsil

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