Has Rotavirus Vaccination Decreased the Prevalence of Biliary Atresia?

Journal of Clinical Gastroenterology
Elizabeth DanialPhilip Rosenthal

Abstract

Biliary atresia (BA) is a rare neonatal liver disease that causes cholestasis and is the leading indication for pediatric liver transplantation. Although the exact etiology of BA remains unknown, evidence from murine models supports the role of rotavirus infection in the development of BA. In 2006, universal rotavirus vaccination was implemented in the United States. The goal of this study was to determine if the prevalence of BA correlated with the number of annual rotavirus infections. We utilized data from the 1997 to 2012 Kids' Inpatient Database and the 1988 to 2015 Organ Procurement and Transplantation Network to determine the annual number of infant discharges with a primary diagnosis of BA and the number of infants with BA who received a liver transplant, respectively. We obtained the number of annual rotavirus infections from the National Respiratory and Enteric Virus Surveillance System and examined whether trends existed between the data from these 3 sources over time. From 1997 to 2006, the number of positive rotavirus antigen tests remained steady, however a rapid decrease was observed from 2006 to 2012 (8774 to 1277), coinciding with the uptake of rotavirus immunizations nationwide. The number of BA discharges dou...Continue Reading

References

Jun 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ronald J SokolFrederick M Karrer
May 2, 2006·The Journal of Pediatrics·Benjamin L ShneiderUNKNOWN Biliary Atresia Research Consortium
Oct 8, 2008·Human Vaccines·Keith Grimwood, Stephen B Lambert
Mar 14, 2009·The Pediatric Infectious Disease Journal·David I Bernstein
Aug 30, 2011·Pediatrics·Yi-Chun LinUNKNOWN Taiwan Infant Stool Color Card Study Group
Nov 30, 2011·Current Opinion in Gastroenterology·Paula M Hertel, Mary K Estes
Jul 13, 2012·The Journal of Surgical Research·Abigail CootsGreg Tiao
Aug 31, 2013·Orphanet Journal of Rare Diseases·Claus Petersen, Mark Davenport
Dec 3, 2014·The Journal of Pediatrics·Maria Grazia ClementeKathleen B Schwarz
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Eyal LeshemUmesh D Parashar
Jul 27, 2017·The Journal of Pediatrics·Perri C HopkinsCade M Nylund

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Citations

Oct 3, 2019·Acta Paediatrica·Maria Grazia ClementePietro Vajro
Mar 5, 2019·F1000Research·Andrew WehrmanRebecca G Wells
Aug 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Mark NomdenJan B F Hulscher

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