Hashimoto's encephalopathy in association with retinitis pigmentosa - First reported case

Journal of Family Medicine and Primary Care
Ritwik GhoshBiman Kanti Ray

Abstract

Hashimoto's Encephalopathy (HE), also known as steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a proteiform disorder known for its wide spectrum of presentations from subtle neuropsychiatric manifestations, movement disorders, seizures, stroke-like episodes to coma. Here, we report a case of HE which initially masqueraded as bipolar affective disorder (BPAD) and ultimately progressed to generalized tonic clonic seizures and coma. Although SREAT is characterized by exquisite responsive to steroid, in our case it was unresponsive to pulse methylprednisolone therapy. Rapid recovery was noted with intravenous immunoglobulin (IVIG) therapy. This case was also peculiar for its association with non-sydnromic retinitis pigmetosa (RP). To the best of our knowledge, this was the first reported case of HE which was associated with RP.

References

Mar 1, 1996·Journal of Endocrinological Investigation·G ScanelliF Padovani
Dec 1, 1996·American Journal of Ophthalmology·S M WhitcupM I Kaiser-Kupfer
Oct 1, 1996·Journal of Endocrinological Investigation·G ProtoF Bertolissi
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S Jacob, Y A Rajabally
Feb 16, 2006·Archives of Neurology·Pablo CastilloBrad Boeve
Apr 2, 2014·Brain, Behavior, and Immunity·Thomas Leyhe, Karsten Müssig
Sep 1, 2013·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kurt SegersMurielle Surquin
Jun 4, 2015·The Journal of Neuropsychiatry and Clinical Neurosciences·Hossam Guirgis, Chetan Amar
Feb 7, 2016·Autoimmunity Reviews·Giacomo MontagnaLuca Giovanella
Mar 30, 2018·Progress in Retinal and Eye Research·Sanne K VerbakelB Jeroen Klevering
Dec 6, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Leonid P ChurilovYuri I Stroev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.