Abstract
Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents in iodine replete areas. To find out the clinical, epidemiological and laboratory characteristics of the disease in childhood, we reviewed files of 162 children and adolescents with HT followed in the Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine. Female patients constituted 86.4% (n = 140) of all patients with a female:male ratio of 6.4. Mean age at diagnosis was 11.4 +/- 2.97 years (age range 4.4-16.5 years). At the time of diagnosis 43.2% of the patients (n = 70) were euthyroid, 24.1% (n = 39) had subclinical hypothyroidism, 21% (n = 34) had overt hypothyroidism, and 8.6% (n = 14) had overt and 3.1% (n = 5) subclinical hyperthyroidism. Autoimmune thyroiditis is more frequent in females, and increases in frequency over age during childhood and adolescence. At the time of diagnosis, frequency of overt and subclinical hypothyroidism is similar to that of euthyroid goiter.
References
Dec 1, 1975·Endocrinologia Japonica·M InoueH Nakajima
Nov 1, 1992·Journal of Pediatric Surgery·W HungG P August
May 1, 1990·European Journal of Pediatrics·N MatsuuraA Hosoda
Dec 1, 1989·Pediatrics in Review·L K Bachrach, T P Foley
Feb 1, 1986·Journal of Clinical Ultrasound : JCU·N HayashiK Endo
Aug 1, 1988·Journal of Pediatric Surgery·J G DesjardinsP Simard
Jun 1, 1985·The Journal of Pediatrics·N MaurasJ R Goellner
Dec 1, 1985·The Journal of Pediatrics·J MäenpääO Wager
Nov 1, 1966·The Journal of Pediatrics·J WinterA M Bongiovanni
Mar 1, 1970·The Journal of Clinical Endocrinology and Metabolism·A H GreenbergR M Blizzard
Jan 1, 1982·Clinical Endocrinology·L Gruñeiro de PapendieckC Bergadá
Apr 1, 1994·The Journal of Pediatrics·K I RotherW F Schwenk
Aug 1, 1993·The Laryngoscope·A P SclafaniH Cho
Dec 1, 1995·The Journal of Pediatrics·N AlosG Van Vliet
Jun 23, 1999·European Journal of Pediatrics·N YordamE Simşek
Aug 5, 2000·Klinische Pädiatrie·B DoekerW Andler
Sep 29, 2001·Acta Cytologica·T SolymosiM Bodo
Apr 9, 2002·Journal of Endocrinological Investigation·G ErdoğanY Genç
Jan 30, 2004·The American Journal of Clinical Nutrition·Michael B ZimmermannYoshimasa Shishiba
Citations
May 11, 2010·Indian Pediatrics·Xu Aijing, Li Tang
Feb 22, 2012·The Tohoku Journal of Experimental Medicine·Ayhan KilicMehmet Yokusoglu
Mar 31, 2011·Journal of Clinical Research in Pediatric Endocrinology·Ayça Törel ErgürMerih Berberoğlu
Aug 23, 2017·La Radiologia medica·Mehmet Öztürk, Ruken Yildirim
Dec 28, 2018·Diagnostic Cytopathology·Dilip K Das
Jan 13, 2009·Clinical and Experimental Immunology·G Guerra-JuniorM Palandi De Mello
May 25, 2012·Diagnostic Cytopathology·Jasleen KaurPranab Dey
Mar 4, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Aysel Burcu Palandokenlier IbiliMehmet Emre Atabek
Apr 24, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hae Sang Lee, Jin Soon Hwang
Aug 16, 2019·Ocular Immunology and Inflammation·Hasan KiziltoprakZehra Aycan
May 3, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Murat DoğanMehmet Selcuk Bektas
Jan 31, 2019·European Journal of Clinical Nutrition·Masoumeh NodehiAli Akbar Saboor-Yaraghi
Feb 11, 2021·Diagnostics·Cristina Mihaela CepehaDana Stoian
Jun 15, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·İrem Ceren ErbaşOlcay Evliyaoğlu