hAT transposable elements and their derivatives: an analysis in the 12 Drosophila genomes.

Genetica
Mauro de Freitas OrtizElgion L S Loreto

Abstract

Transposable elements (TEs) comprise a significant fraction of the genome, and some models of the TE "life cycle" suggest that, in the last phases of the cycle, TEs should be represented, in the genomes, by inactive and degenerated copies. In this study, we analyzed, using a bioinformatics approach, the autonomous hAT elements and their derivatives (active non-autonomous, MITE relatives and degenerated copies) in 12 Drosophila genomes. We found 28 hAT elements that had derivatives. Most copies had features that suggested that they were active, while only a few degenerated copies were found. Because hAT elements comprise an evolutionarily old superfamily, one should expect to find many degenerated copies within the genome, although this was not observed in our study. These results suggest that primarily active copies of hAT elements are maintained in the euchromatic regions of the genome and that degenerated copies are removed from the genome by natural selection.

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Citations

Jan 17, 2012·Plant Molecular Biology·Gerhard MenzelThomas Schmidt
Dec 23, 2011·Genetics Research·Elaine Silva Dias, Claudia Marcia Aparecida Carareto
Nov 8, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Gerhard MenzelThomas Schmidt
Dec 13, 2006·Gene·Luciane M AlmeidaM Elisabete J Amaral
May 3, 2018·Genetics·Patrick M O'Grady, Rob DeSalle
Apr 19, 2018·Genetics and Molecular Biology·Elgion L S LoretoVera Lucia S Valente-Gaiesky

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