hAT Transposable Elements

Microbiology Spectrum
Peter W Atkinson

Abstract

hAT transposons are ancient in their origin and they are widespread across eukaryote kingdoms. They can be present in large numbers in many genomes. However, only a few active forms of these elements have so far been discovered indicating that, like all transposable elements, there is selective pressure to inactivate them. Nonetheless, there have been sufficient numbers of active hAT elements and their transposases characterized that permit an analysis of their structure and function. This review analyzes these and provides a comparison with the several domesticated hAT genes discovered in eukaryote genomes. Active hAT transposons have also been developed as genetic tools and understanding how these may be optimally utilized in new hosts will depend, in part, on understanding the basis of their function in genomes.

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May 18, 2016·Chemical Reviews·Alison B Hickman, Fred Dyda
Dec 3, 2016·Nucleic Acids Research·Lauren E WoodardMatthew H Wilson
Jan 27, 2018·Journal of Fungi·Theo N KirklandJason E Stajich
Feb 6, 2020·Nature Structural & Molecular Biology·Xuemin ChenMartin Gellert
Mar 25, 2019·Frontiers in Microbiology·Matthieu LegendreJean-Michel Claverie
Feb 6, 2020·Nature Structural & Molecular Biology·Xuemin ChenWei Yang

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