Hath1 up-regulates gastric mucin gene expression in gastric cells

Biochemical and Biophysical Research Communications
Akiko SekineYasuhito Yuasa

Abstract

The Notch signaling pathway is known to mediate the differentiation and fate specification of cells in embryonic stage and adult tissues. Several tumors exhibit aberrant expression of Notch signaling component genes, such as Notch1/2/3 and Hath1. In this study, we investigated the mRNA expression of seven Notch-related genes, Notch1/2/3, Hes1/2/3, and Hath1, and then compared it with the expression of gastric mucin genes, MUC5AC and MUC6, in eight gastric cancer (GC) cell lines. Notch1/2/3 and Hes1 were expressed in most GC cell lines as well as normal gastric mucosae, while Hes2/3 were expressed in neither these cell lines nor the normal stomach. As for Hath1, five GC cell lines exhibited undetectable levels, while normal gastric mucosa expressed Hath1. The expression patterns of Hath1 and MUC6 were closely related in most GC cell lines. Many MUC5AC-positive cases also tended to show Hath1 expression. Over-expression of Math1, a mouse Hath1 homolog, in the GC cells strongly enhanced both the MUC6 and MUC5AC mRNA levels. Moreover, knockdown of Hath1 by means of RNA interference significantly decreased the expression of both mucin genes. These data indicate that Hath1 is one of the transcriptional regulators for MUC6 and MUC5AC ...Continue Reading

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Citations

Apr 9, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Slavica StojnevTakanori Hattori
Jun 10, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xin ZhangRongquan Wang
Jan 19, 2010·Carcinogenesis·Yutaka HashimotoYasuhito Yuasa
Apr 21, 2012·International Journal of Otolaryngology·Yoshihisa NakamuraJizhen Lin
Oct 8, 2011·Current Colorectal Cancer Reports·Avedis Kazanjian, Noah F Shroyer
Mar 14, 2009·Differentiation; Research in Biological Diversity·Michael GersemannEduard Friedrich Stange
May 20, 2016·Life Sciences·Harishankar MkArikketh Devi
May 31, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin Hyun KangIl Yup Chung
Jul 23, 2020·Frontiers in Cell and Developmental Biology·Guo-Lian GanWei Li
Jan 18, 2012·Oncotarget·Giulia PiazziLuigi Ricciardiello

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