Have the new drugs relieved the burden of the orthopedic surgeon?

Current Opinion in Rheumatology
G Pap, Y Shigeyama

Abstract

Rheumatoid arthritis (RA) represents a chronic joint inflammation that leads to destructive lesions of joint cartilage and periarticular bone. Increased understanding of the molecular and cellular mechanisms of RA and recent advantages in molecular technology have resulted in new antirheumatic drugs such as tumor necrosis factor-alpha blockers, inhibitors of interleukin-1, and novel disease-modifying antirheumatic drugs such as leflunomide. This review summarizes the important effects of the novel antirheumatic drugs and their potential impact on the work of orthopedic surgeons. The ability of these agents not only to improve the clinical signs and symptoms of RA but also to prevent progressive joint damage promises support to the work of orthopedic surgeons and to the interdisciplinary treatment of RA patients. The challenge, however, will be to conduct studies that show the concrete way in which the single drugs may best relieve the burden of the orthopedic surgeon.

References

Mar 1, 1991·Zeitschrift für Orthopädie und ihre Grenzgebiete·K Tillmann
Oct 1, 1989·Acta Orthopaedica Scandinavica·H C DoetsR M von Soesbergen
Mar 1, 1997·Arthritis and Rheumatism·L W MorelandW J Koopman
May 1, 1997·Immunology Today·L Adorini, F Sinigaglia
May 6, 1998·Current Opinion in Rheumatology·B C Toolan, S T Hansen
Nov 4, 1998·The Journal of Bone and Joint Surgery. American Volume·M G CreightonR C Johnston
Dec 4, 1998·Springer Seminars in Immunopathology·C Gabay, W P Arend
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Jan 28, 1999·The New England Journal of Medicine·J R O'Dell
Mar 13, 1999·Annals of Internal Medicine·L W MorelandM E Weinblatt
May 18, 1999·Osteoarthritis and Cartilage·S GayR E Gay
Jul 10, 1999·Drugs·B Jarvis, D Faulds
Sep 29, 1999·Zeitschrift für Rheumatologie·H P JüstenD Wessinghage
Dec 1, 1999·Annals of the Rheumatic Diseases·B Bresnihan
Jan 11, 2000·Clinical Orthopaedics and Related Research·E R Bogoch, E L Moran
Jan 11, 2000·Clinical Orthopaedics and Related Research·M J Chmell, R D Scott
Jan 11, 2000·Clinical Orthopaedics and Related Research·D Hargreaves, R Emery
Jan 11, 2000·Clinical Orthopaedics and Related Research·J K Stanley
Mar 16, 2000·The New England Journal of Medicine·D S Pisetsky
Mar 24, 2000·Zeitschrift für Orthopädie und ihre Grenzgebiete·T PitzenW I Steudel
Apr 6, 2000·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·S KlugG Weseloh
Apr 25, 2000·Scandinavian Journal of Rheumatology·O FørreW G Hassfeld
May 10, 2000·Current Opinion in Rheumatology·S Gay
May 10, 2000·Current Opinion in Rheumatology·S R Goldring, E M Gravallese
Sep 23, 2000·Rheumatology·J S Smolen, P Emery
Nov 4, 2000·Expert Opinion on Investigational Drugs·C Gabay
Nov 18, 2000·Arthritis and Rheumatism·Y ShigeyamaS Gay
Nov 28, 2000·Scandinavian Journal of Rheumatology·D ChristenssonU Rydholm
Nov 30, 2000·The New England Journal of Medicine·J M BathonB K Finck

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.