Hawaiienols A-D, Highly Oxygenated p-Terphenyls from an Insect-Associated Fungus, Paraconiothyrium hawaiiense

Journal of Natural Products
Fengxia RenYongsheng Che

Abstract

Four new highly oxygenated p-terphenyls, hawaiienols A-D (1-4), have been isolated from cultures of Paraconiothyrium hawaiiense, a fungus associated with the Septobasidium-infected insect Diaspidiotus sp.; their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2-4 were assigned by single-crystal X-ray diffraction analysis using Cu Kα radiation and via electronic circular dichroism calculations, respectively. Compound 1 incorporated the first naturally occurring 4,7-dioxatricyclo[3.2.1.03,6]octane unit in its p-terphenyl skeleton and showed cytotoxicity toward six human tumor cell lines.

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Citations

Sep 14, 2018·Natural Product Reports·Robert A Hill, Andrew Sutherland
May 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Hua ZhangYue-Hu Pei
Jan 6, 2019·Applied Microbiology and Biotechnology·Vera VilValery M Dembitsky
Nov 19, 2019·Journal of Asian Natural Products Research·Yan Fei Liu, Shi-Shan Yu
Dec 17, 2019·Folia Microbiologica·Cuiping MiaoShaohua Wu
Jul 3, 2021·Critical Reviews in Microbiology·Junfei WangShaohua Wu

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