Hawthorn Polyphenol Extract Inhibits UVB-Induced Skin Photoaging by Regulating MMP Expression and Type I Procollagen Production in Mice

Journal of Agricultural and Food Chemistry
Suwen LiuXuedong Chang

Abstract

Ultraviolet (UV) B radiation can cause skin aging by increasing matrix metalloproteinase (MMP) production and collagen degradation, leading to the formation of wrinkles. This study investigated whether hawthorn polyphenol extract (HPE) protects against UVB-induced skin photoaging using HaCaT human keratinocytes, normal human dermal fibroblasts (HDFs), and mice. Analysis of the phenol composition of HPE by high-performance liquid chromatography-mass spectrometry showed that chlorogenic acid (13.5%), procyanidin B2 (19.2%), and epicatechin (18.8%) collectively accounted for 51.4% of total phenol content and represent the active ingredients of hawthorn fruit. A cell viability assay revealed that HPE treatment promoted cell proliferation in HaCaT cells and HDFs. On the other hand, MMP-1 and type I procollagen production was decreased and increased, respectively, in UVB-exposed cells treated with HPE as compared with those without treatment, as determined by enzyme-linked immunosorbent assay. Hematoxylin and eosin and Weigert staining of dermal tissue specimens from mice demonstrated that HPE also reversed UVB-induced epidermal thickening and dermal damage. The increase in production of reactive oxygen species and decrease in antiox...Continue Reading

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Citations

May 2, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Kyung Eun LeeSang Gu Kang
Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Apr 22, 2020·Aging·Hongyi WangKai Tao
Oct 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying BaiHang Qi
Jan 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Mi KangHyo-Jin An
Apr 29, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Wei GaoYu-Shuai Wang
May 30, 2020·Ecotoxicology and Environmental Safety·Jie DengMeiying Li
Nov 11, 2020·Mini Reviews in Medicinal Chemistry·Fatemeh FarjadmandMina Saeedi

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