Hazard assessment of boric acid in toys

Regulatory Toxicology and Pharmacology : RTP
A G CraanD W Green

Abstract

Boric acid (H3BO3) has been used in a wide variety of applications--medication, pesticides, and household products. Reports of child poisoning by H3BO3 were common in the clinical literature before 1975. However, a decline in its use as a bacteriostatic agent coupled with increased regulatory control has almost eliminated poisonings by accidental ingestion. Schedule I (Part I, Item 8) of the Hazardous Products Act of Canada, proclaimed in the late 1960s, followed in the wake of concerns about accidental poisoning and prohibits its use in toys. Since that time, scientific knowledge has increased and has led to a reevaluation of the hazard associated with H3BO3. A maximum tolerated dose (MTD) was sought for children in the most susceptible age range, with a view to determine a maximum acceptable concentration (MAC) in toys. The effects of H3BO3 in a variety of exposure scenarios were evaluated. Precedence was given to clinical data in humans, particularly children, since there is no suitable animal model of boric acid intoxication. An extensive search of the pediatric literature was conducted to find a no-observed-adverse-effect level (NOAEL) or a lowest-observed-adverse-effect level (LOAEL). An analysis of the pivotal study to t...Continue Reading

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Citations

Jun 13, 2012·Journal of Toxicology and Environmental Health. Part a·Hermann M BoltYalçın Duydu
Jun 12, 2017·Archives of Toxicology·Hermann M BoltKlaus Golka
Jan 6, 2011·Analytical Chemistry·Farid OukacineHervé Cottet

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