Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance

Critical Reviews in Food Science and Nutrition
Joana CostaMaria Beatriz P P Oliveira

Abstract

In last few years, special attention has been given to food-induced allergies, in which hazelnut allergy is highlighted. Hazelnut is one of the most commonly consumed tree nuts, being largely used by the food industry in a variety of processed foods. It has been regarded as a food with potential health benefits, but also as a source of allergens capable of inducing mild to severe allergic reactions in sensitized individuals. Considering the great number of reports addressing hazelnut allergens, with an estimated increasing trend, this review intends to assemble all the relevant information available so far on the following main issues: prevalence of tree nut allergy, clinical threshold levels, molecular characterization of hazelnut allergens (Cor a 1, Cor a 2, Cor a 8, Cor a 9, Cor a 10, Cor a 11, Cor a 12, Cor a 14, and Cor a TLP) and their clinical relevance, and methodologies for detection of hazelnut allergens in foods. A comprehensive overview of the current data about the molecular characterization of hazelnut allergens is presented, relating to biochemical classification and biological function with clinical importance. Recent advances in hazelnut allergen detection methodologies are summarized and compared, including al...Continue Reading

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Citations

Sep 3, 2016·Clinical Reviews in Allergy & Immunology·Cíntia MendesIsabel Mafra
Sep 20, 2017·Critical Reviews in Food Science and Nutrition·Joana CostaIsabel Mafra
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Jun 3, 2021·Foods·Cristobalina MayorgaFrancisca Gómez

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Datasets Mentioned

BETA
AAR22488
ADR66948
AAF26449
AAB00861.1
ABV49593.1

Methods Mentioned

BETA
electrophoresis
glycosylation
enzyme-linked
biosensors
ELISA
Assay
biosensor
surface plasmon resonance
PCR-ELISA
PCR

Software Mentioned

nsLTP
Blast
EuroPrevall

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