Hazelnut and cocoa spread improves flow-mediated dilatation in smokers

Internal and Emergency Medicine
Lorenzo LoffredoFrancesco Violi

Abstract

Hazelnut and cocoa spread is an Italian product containing cocoa and hazelnut. Several epidemiological studies suggest that cocoa and hazelnuts cocoa exert beneficial cardiovascular effects. To investigate whether in smokers, hazelnut and cocoa spread elicits artery dilatation via down-regulation of oxidative stress. Flow-mediated dilatation (FMD), oxidative stress (as assessed by serum isoprostanes excretion, Nox2 activation and NO bioavailability) and antioxidant status [as assessed by vitamin E levels, plasma total polyphenols and H2O2 breaking down activity (HBA)] were studied in 20 smokers in a crossover, single-blind study. Patients were randomly allocated to 60 g of Hazelnut and cocoa spread or 60 g of milk chocolate (≤ 35% cocoa). FMD, serum isoprostanes, Nox2 activation, NOx, vitamin E, HBA and total polyphenols were assessed at baseline and 2 h after chocolate ingestion. After Hazelnut and cocoa spread intake, FMD and NOx significantly increased (from 4.3 ± 2.8 to 8.0 ± 3.2%, p < 0.001 and from 23.1 ± 5.5 to 32.0 ± 12.6 µM, p = 0.016, respectively); conversely, serum isoprostanes and Nox2 activation significantly decreased (from 302.8 ± 59.8 to 240.7 ± 90.8 pmol/l, p = 0.03 and from 25 ± 4.4 to 22.6 ± 3.2, p = 0.03, r...Continue Reading

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Citations

Oct 6, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Maria Del BenFrancesco Violi
Nov 3, 2020·Oxidative Medicine and Cellular Longevity·Natalia Di PietroCaterina Pipino
Mar 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Ángeles Martin, Sonia Ramos

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