Hb A2/E levels found in co-inheritance with the α-thalassemia-1 - -(SEA)/type deletion and either Hb E or β-thalassemia

Hemoglobin
Sakorn PornprasertKunyakan Kongthai

Abstract

The α-thalassemia-1 (α-thal-1) Southeast Asian (- -(SEA)) type deletion, β-thalassemia (β-thal) and Hb E [β26(B8)Glu→Lys, GAG>AAG] are the most common genetic disorders in Southeast Asian populations. Mean corpuscular volume (MCV) <80.0 fL with normal hemoglobin (Hb) is used for screening α- and β-thal, and a Hb E level of less than 25.0% is used for predicting α-thal-1 in Hb E trait. Thus, levels of Hb, MCV and Hb A(2)/E were reviewed and compared between the SEA type deletion co-inherited with β-thal trait (n = 61), with Hb E trait (n = 102) or homozygous Hb E (n = 13) and β-thal trait (n = 636), Hb E trait (n = 544) or homozygous Hb E (n = 83), respectively. When comparing the values of all three analyzed hematological parameters, only the - -(SEA)/β(E) values were shown to be significantly lower than those of Hb E trait. Furthermore, at a cut-off value of Hb A(2)/E of 21.54%, 95.0% of the - -(SEA)/β(E) had Hb A(2)/E levels lower than this cut-off value, while 94.0% of Hb E trait had Hb A(2)/E at higher levels. Accordingly, the Hb A(2)/E level at 21.54% is the best indicator for predicting co-inheritance of the α-thal-1 - -(SEA)/ deletion and Hb E trait.

References

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Citations

Jun 19, 2014·Hemoglobin·Sakorn Pornprasert, Kanokwan Jaiping
Aug 16, 2013·Hemoglobin·Sakorn Pornprasert, Siratcha Phanthong
Dec 22, 2017·Laboratory Medicine·Sakorn PornprasertChaowanee Wangchauy
Jul 8, 2020·Hematology·Chantana PolprasertPonlapat Rojnuckarin
Feb 21, 2020·The Journal of Obstetrics and Gynaecology Research·Chanhathai NunchaiTheera Tongsong

Related Concepts

High Pressure Liquid Chromatography Procedure
Mean Corpuscular Hemoglobin Concentration Determination
Hemoglobin A2
Hemoglobin E
Retrospective Studies
Alpha-Thalassemia
Thalassemia Minor
Deletion Mutation
Korean Race
Kinetic Polymerase Chain Reaction

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