HB-EGF: a unique mediator of embryo-uterine interactions during implantation.

Experimental Cell Research
Hyunjung Jade Lim, S K Dey

Abstract

An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for long-range interactions and membrane-bound molecules for more immediate interactions. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process.

Associated Clinical Trials

References

Jan 1, 1988·Annals of the New York Academy of Sciences·K Yoshinaga
Jan 1, 1973·Vitamins and Hormones·A Psychoyos
Dec 1, 1966·Journal of Reproduction and Fertility·K Yoshinaga, C E Adams
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B C PariaS K Dey
Nov 20, 1998·Molecular Reproduction and Development·A KliemB Fischer
Jul 7, 2000·Developmental Biology·D D CarsonK Yoshinaga
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·B C PariaB L Hogan
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·R E LeachA T Fazleabas
Oct 29, 2002·Lancet·Richard E LeachD Randall Armant
Jun 8, 2004·Endocrine Reviews·S K DeyHaibin Wang
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Toshio HamataniSudhansu K Dey
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
Apr 20, 2007·Glycobiology·Mary C Farach-Carson, Daniel D Carson
Nov 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Huirong XieSudhansu K Dey

❮ Previous
Next ❯

Citations

Nov 16, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·M G Martínez-HernándezD Randall Armant
Mar 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sanjoy K Das
Jun 20, 2014·Human Reproduction Update·Martina ColicchiaCostanzo Moretti
Apr 7, 2010·The Journal of Clinical Investigation·Hyunjung Jade Lim, Haibin Wang
Oct 27, 2010·PloS One·Francisco DomínguezMaría Yáñez-Mó
Jan 8, 2013·Molecular Aspects of Medicine·Shuang ZhangD Randall Armant
Dec 12, 2012·Nature Medicine·Jeeyeon ChaSudhansu K Dey
Sep 18, 2010·Molecular Human Reproduction·G TeklenburgJan J Brosens
Jun 8, 2011·Journal of Reproductive Immunology·Ruth Grümmer, Elke Winterhager
Feb 14, 2015·Taiwanese Journal of Obstetrics & Gynecology·Kemal OzbilginTayfun Ozcakir
Oct 17, 2012·Molecular Reproduction and Development·Shuang ZhangHaibin Wang
Jul 1, 2009·Molecular Reproduction and Development·Philip JessmonD Randall Armant
Mar 13, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Lien M Davidson, Kevin Coward
Jan 21, 2011·Biology of Reproduction·Griselda VallejoPatricia Saragüeta
Nov 9, 2018·Human Reproduction Update·Amma Owusu-AkyawSara S Morelli
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Jan 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hai-Fan YuBin Guo
Jun 1, 2013·Reproductive Medicine and Biology·Mahiro Egashira, Yasushi Hirota
Jan 4, 2017·Journal of Cell Science·John D Aplin, Peter T Ruane
Dec 14, 2018·Experimental and Therapeutic Medicine·Hui WangLi Sheng
Apr 3, 2020·International Journal of Environmental Research and Public Health·Mohd Helmy MokhtarNaguib Salleh
Jul 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Oliver W GriffithGunter P Wagner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Huirong XieSudhansu K Dey
Molecular Reproduction and Development
Philip JessmonD Randall Armant
Seminars in Cell & Developmental Biology
B C PariaS K Dey
Endocrine Reviews
S K DeyHaibin Wang
© 2022 Meta ULC. All rights reserved