PMID: 602924Jan 1, 1977Paper

Hb Leiden-beta (0) thalassemia in a Chinese with severe hemolytic anemia

American Journal of Hematology
L E Lie-InjoJ P Kane

Abstract

The first case of Hb Leiden (alpha2beta2 6 or 7 Glu---O)-beta (0) thalassemia in a young patient with chronic severe hemolytic anemia, which improved after splenectomy, is described. His parents were Chinese. The patient's blood showed no Hb A or normal beta chains when no blood transfusion was given. His mother was heterozygous for beta(0) thalassemia, and his father and brother had a trait for the unstable Hb Leiden. The Hb Leiden level of the father was 22.6% and that of the brother was 19.3%. It is probable that the abnormal hemoglobin in this Chinese family resulted from an independent gene mutation, unrelated to the one found in 2 Caucasian families reported earlier.

References

Feb 4, 1976·Journal of Chromatography·L Lie-Injo
Oct 1, 1974·The Journal of Clinical Investigation·R F Rieder, G W James
Nov 1, 1972·British Journal of Haematology·R W Carrell, R Kay
Sep 1, 1972·Journal of Medical Genetics·L L EngH Lehmann
Nov 23, 1968·Nature·W W De JongL F Bernini
Mar 12, 1966·Nature·D BealeE M Tucker
Jul 1, 1964·British Journal of Haematology·J V DACIEJ C WHITE

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Citations

Dec 1, 1982·Biochemical Genetics·W A SchroederA A Bedros
Sep 24, 1981·The New England Journal of Medicine·E C Zaino, Y Y Tien
Apr 16, 2015·Scandinavian Journal of Clinical and Laboratory Investigation·Marco RosettiRomolo M Dorizzi
Sep 18, 1999·Hemoglobin·J D HoyerV F Fairbanks

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