HbA1c levels in children with type 1 diabetes and correlation to diabetic retinopathy.

Journal of Pediatric Endocrinology & Metabolism : JPEM
Rebecka AndreassonCharlotta Nilsson

Abstract

Type 1 diabetes mellitus (T1D) is a metabolic disease causing hyperglycemia due to β-cell destruction. Despite adequate treatment, complications such as diabetic retinopathy (DR) are common. The first aim was to investigate if acute onset of type 1 diabetes differed between those who had developed retinopathy and who had not after 15 years from diagnosis. The second aim was to investigate if mean glycosylated hemoglobin (HbA1c) levels affect the time to development of DR. The medical records of all children and adolescents diagnosed with type 1 diabetes during 1993-2001 in our area in Sweden were studied retrospectively and the mean HbA1c each year until the development of retinopathy was investigated. In total 72 patients were included and the follow-up time was between 15 and 23 years. Gender, p-glucose, age and HbA1c at diagnosis were analyzed for possible correlations to years to retinopathy. HbA1c was significantly higher among those who had developed DR after 15 years from diagnosis, 98±9.2 (n=25) vs. 86±9.2 (n=46; p=0.025). A negative correlation was found between age at diagnosis and years to DR (rs=-0.376; p=0.026). Mean HbA1c levels at years 6-10 after diabetes diagnosis correlated significantly (rs=-0.354, p=0.037) t...Continue Reading

References

Feb 19, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·E BognettiG Chiumello
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·C E KullbergUNKNOWN VISS Study Group
Feb 14, 2003·Archives of Ophthalmology·Hendrik A van LeidenBettine C P Polak
Jul 25, 2007·Diabetes, Obesity & Metabolism·M TyrbergU Lindblad
Jan 29, 2008·Clinical Chemistry·Cas WeykampCarla Siebelder
Apr 8, 2009·International Ophthalmology Clinics·Gerald LiewTien Y Wong
Jun 4, 2010·Diabetes Care·Ragnar HanasUNKNOWN International HBA1c Consensus Committee
Mar 30, 2012·The New England Journal of Medicine·David A AntonettiThomas W Gardner
Dec 18, 2013·Diabetes Research and Clinical Practice·Chris PattersonMartin Silink
Jan 10, 2014·Current Genomics·Olga Simó-ServatRafael Simó
Feb 15, 2014·The Cochrane Database of Systematic Reviews·Birgit FullertonAndrea Siebenhofer
Mar 13, 2014·PloS One·Julia M HermannUNKNOWN DPV Initiative the German BMBF Competence Network Diabetes Mellitus
Jun 22, 2014·Current Diabetes Reports·Heeyoon Cho, Lucia Sobrin
Sep 10, 2014·Journal of Endocrinological Investigation·Z-H TangK Zhang
Sep 2, 2015·Journal of Biomedical Informatics·Simone MariniRiccardo Bellazzi
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Sep 23, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Stuart KeelLaima Brazionis

❮ Previous
Next ❯

Citations

Oct 17, 2019·Pediatric Diabetes·Camilla W HerskinJesper Johannesen
Sep 23, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ozlem Kara, Mehmet Erol Can
Feb 14, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Eren ErDamla Gökşen

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.