HbA1c negatively correlates with LCAT activity in type 2 diabetes

Diabetes Research and Clinical Practice
Manouchehr NakhjavaniSaeideh Hashemi

Abstract

Abnormal high-density lipoproteins (HDL) metabolism is a major cardiovascular risk factor in type 2 diabetes mellitus (DM2). Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol. The purpose of this study was to determine the independent correlates of LCAT activity in DM2 patients. A total of 45 (male: 20) consecutive adult DM2 patients aging 50.0+/-7.0 years (range: 40-64 years) with a median diabetes duration of 4 years (range: 2-18) were studied. Exclusion criteria were: smoking, positive history of cardiovascular, thyroid, renal or liver disease, pregnancy, treatment with metformin, insulin, lipid lowering drugs, angiotensin-converting enzyme inhibitors, aspirin or antioxidant supplements. Univariate and multivariate analyses were performed. From a comprehensive list of variables studied, only HbA1c (rho=-0.951) and oxidized LDL (rho=-0.779) had statistically significant correlation with LCAT activity (p<0.001). These two variables were themselves strongly correlated to each other (rho=0.809, p<0.001). To eliminate potential confounding effects, we performed multivariate analysis, where HbA1c emerged as a strong ind...Continue Reading

References

Dec 1, 1991·The Journal of Clinical Investigation·C J MannB E Bihain
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·C BaynesR S Elkeles
Apr 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·C CalvoC Verdugo
Sep 21, 2001·Biochemical and Biophysical Research Communications·T MatsunagaT Komoda
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Mertens, P Holvoet
Apr 12, 2002·Trends in Endocrinology and Metabolism : TEM·Weijun JinDaniel J Rader

Citations

Mar 7, 2012·Expert Review of Cardiovascular Therapy·Dan Farbstein, Andrew P Levy
Oct 5, 2010·The American Journal of the Medical Sciences·Manouchehr NakhjavaniMehdi Anvari
Nov 13, 2012·Life Sciences·Manouchehr NakhjavaniAlireza Esteghamati
Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Douja Taleb-SenouciMalika Bouchenak
Jul 20, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giuliano GenerosoMarcio Sommer Bittencourt
Jan 25, 2019·Cardiovascular Drugs and Therapy·Scott T Chiesa, Marietta Charakida

Related Concepts

Blood Glucose
Diastolic Blood Pressure
Epicholesterol
Diabetes Mellitus, Non-Insulin-Dependent
Fasting
Hb A1a-2
Phosphatidylcholine-Sterol O-Acyltransferase
Lipids
Multivariate Analysis
Selection of Subjects

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