HbA1c negatively correlates with LCAT activity in type 2 diabetes

Diabetes Research and Clinical Practice
Manouchehr NakhjavaniSaeideh Hashemi


Abnormal high-density lipoproteins (HDL) metabolism is a major cardiovascular risk factor in type 2 diabetes mellitus (DM2). Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol. The purpose of this study was to determine the independent correlates of LCAT activity in DM2 patients. A total of 45 (male: 20) consecutive adult DM2 patients aging 50.0+/-7.0 years (range: 40-64 years) with a median diabetes duration of 4 years (range: 2-18) were studied. Exclusion criteria were: smoking, positive history of cardiovascular, thyroid, renal or liver disease, pregnancy, treatment with metformin, insulin, lipid lowering drugs, angiotensin-converting enzyme inhibitors, aspirin or antioxidant supplements. Univariate and multivariate analyses were performed. From a comprehensive list of variables studied, only HbA1c (rho=-0.951) and oxidized LDL (rho=-0.779) had statistically significant correlation with LCAT activity (p<0.001). These two variables were themselves strongly correlated to each other (rho=0.809, p<0.001). To eliminate potential confounding effects, we performed multivariate analysis, where HbA1c emerged as a strong ind...Continue Reading


Dec 1, 1991·The Journal of Clinical Investigation·C J MannB E Bihain
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·C BaynesR S Elkeles
Apr 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·C CalvoC Verdugo
Sep 21, 2001·Biochemical and Biophysical Research Communications·T MatsunagaT Komoda
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Mertens, P Holvoet
Apr 12, 2002·Trends in Endocrinology and Metabolism : TEM·Weijun JinDaniel J Rader


Mar 7, 2012·Expert Review of Cardiovascular Therapy·Dan Farbstein, Andrew P Levy
Oct 5, 2010·The American Journal of the Medical Sciences·Manouchehr NakhjavaniMehdi Anvari
Nov 13, 2012·Life Sciences·Manouchehr NakhjavaniAlireza Esteghamati
Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Douja Taleb-SenouciMalika Bouchenak
Jul 20, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giuliano GenerosoMarcio Sommer Bittencourt
Jan 25, 2019·Cardiovascular Drugs and Therapy·Scott T Chiesa, Marietta Charakida

Related Concepts

Blood Glucose
Diastolic Blood Pressure
Diabetes Mellitus, Non-Insulin-Dependent
Hb A1a-2
Phosphatidylcholine-Sterol O-Acyltransferase
Multivariate Analysis
Selection of Subjects

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.