HbA1C Variability Is Strongly Associated With the Severity of Peripheral Neuropathy in Patients With Type 2 Diabetes

Frontiers in Neuroscience
Yun-Ru LaiCheng-Hsien Lu

Abstract

Variability in HbA1c is associated with a higher risk of cardiovascular disease and microvascular complications in patients with type 2 diabetes. The present study evaluated the severity of somatic nerve dysfunction at different stages of chronic glycemic impairment, and its correlation with different cardio-metabolic parameters. The study was conducted on 223 patients with type 2 diabetes. We calculated the intrapersonal mean, standard deviation (SD), and coefficient of variation of HbA1c for each patient using all measurements obtained for 3 years prior to the study. Patients were divided into quartiles according to the SD of HbA1c, and we constructed composite scores of nerve conduction as the severity of peripheral neuropathy. Linear regression analysis was performed to evaluate the influence of independent variables on mean composite scores. Those with higher SD-HbA1c had a higher body mass index, mean and index HbA1c, triglyceride and uric acid level, urinary albumin excretion and albumin-creatinine ratio, proportion of insulin therapy, and prevalence of hypertension as the underlying diseases, but lower estimate glomerular filtration rate (eGFR). In addition, those with higher SD-HbA1c showed lower amplitudes and reduced...Continue Reading

References

Dec 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·A VevesA J Boulton
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Mar 29, 2005·Diabetes Care·Andrew J M BoultonUNKNOWN American Diabetes Association
Feb 8, 2006·Postgraduate Medical Journal·V BansalU K Misra
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Michael Brownlee, Irl B Hirsch
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Dec 8, 2009·Endocrine Reviews·Sarah E SiegelaarJ Hans DeVries
Jun 23, 2011·Diabetes/metabolism Research and Reviews·Peter J DyckUNKNOWN Toronto Expert Panel on Diabetic Neuropathy
Oct 15, 2011·Muscle & Nerve·Peter J DyckWilliam J Litchy
Jul 12, 2014·Journal of the Neurological Sciences·N SuanprasertP J Dyck
Jul 8, 2016·Endocrine·Heung Yong JinTae Sun Park
Oct 30, 2016·Journal of Clinical and Diagnostic Research : JCDR·Debahuti Mohapatra, Komaladevi Sampath Damodar
May 10, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yongze ZhangSunjie Yan
Mar 31, 2018·Cardiovascular Diabetology·Jian-Bin SuXue-Qin Wang
Jun 27, 2018·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Fan-Fan Zhu, Li-Zhen Yang

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Citations

Oct 16, 2019·Muscle & Nerve·Yun-Ru LaiCheng-Hsien Lu
Oct 5, 2019·QJM : Monthly Journal of the Association of Physicians·Y-R LaiC-H Lu
Jul 6, 2020·Cardiovascular Diabetology·Zheng ZhouMeng Bian
Oct 20, 2020·Frontiers in Endocrinology·Marie Mathilde Bjerg ChristensenChristian Stevns Hansen
Nov 22, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yun-Ru LaiCheng-Hsien Lu
Jul 3, 2020·Diabetes Research and Clinical Practice·Fengwen LiWeiping Jia
Jul 27, 2021·Frontiers in Microbiology·Yu-Hang ZhangYu-Dong Cai

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Methods Mentioned

BETA
amputation

Software Mentioned

SAS

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