PMID: 46655Jan 1, 1975

HBs antigen in human plasma fractions

Vox Sanguinis
P LevequeJ Malgras

Abstract

Therapeutic fractions were obtained by fractionating human plasma containing HBs antigen, by the Cohn ethanol technique modified by Nitschmann. Plasmas with various HBs antigen titers were selected. The antigen was sought in each fraction by the techniques of counterelectrophoresis and radioimmunological detection in liquid phase. With the exception of very pure albumins, all fractions were found to contain the HBs antigen, though in variable proportions. A technique for the purification of albumin, applicable on an industrial scale, is proposed. It makes it possible to obtain an albumin fraction in which the HBs antigen cannot be detected by the most sensitive techniques, even starting with a plasma which is very rich in HBs antigen (titer 1/64 by counterelectrophoresis).

References

Jan 1, 1978·Vox Sanguinis·V de Villiers, J G Wilson
Jan 1, 1978·Vox Sanguinis·M H Viljoen
May 1, 1976·CRC Critical Reviews in Clinical Laboratory Sciences·E S Meek, M L O'Connor

Citations

Sep 1, 1970·Vox Sanguinis·K AndrassyR Sanwald
Mar 1, 1971·Vox Sanguinis·H BeckK H Stürner
Sep 20, 1965·JAMA : the Journal of the American Medical Association·J W MOSLEY
Nov 20, 1948·Journal of the American Medical Association·C A JANEWAY

Related Concepts

Immunoelectrophoresis
Hepatitis B Antigens
ALB
Serum Proteins
Factor VIII Procoagulant Activity
Gamma globulin
Plasma Albumin
Blood Coagulation Factor
Radioimmunoassay
Hydrogen-Ion Concentration

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.