PMID: 69633Jul 1, 1977Paper

HBsAg and HBcAg in the livers of asymptomatic hepatitis B antigen carriers

Journal of Clinical Pathology
E Tapp, D M Jones

Abstract

Asymptomatic blood donors with persistent HBs antigenaemia have a variety of histological lesions in the liver, and serial biopsies indicate that, in some, these lesions may progress. The immunoperoxidase technique was found to be a sensitive method for the histological demonstration of HBsAg and HBcAg. Livers showing minor histological changes contained more HBsAg than those with active lesions and there appears to be an inverse relationship between the amount of HBsAg in the liver and the severity of the histological damage. In the carriers who had more than one biopsy, the presence of stainable HBsAg, irrespective of the initial histological diagnosis, was associated with a greater likelihood of progression of the histological lesion. HBcAg was found only in the hepatocyte nuclei of carriers with chronic aggressive and chronic persistent hepatitis.

References

Jan 1, 1975·Journal of Clinical Pathology·K P DeodharP J Scheuer
Apr 1, 1976·American Journal of Clinical Pathology·A P AfroudakisR L Peters
Oct 1, 1976·Journal of Clinical Pathology·E TappI W Dymock
Nov 1, 1975·British Journal of Haematology·D Y MasonC R Taylor
May 1, 1974·Journal of Clinical Pathology·I L WoolfI W Dymock

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Citations

Jan 1, 1979·Vox Sanguinis·P UkkonenK Penttinen
Feb 1, 1981·Vox Sanguinis·G HessK H Meyer zum Büschenfelde
Jan 1, 1980·Vox Sanguinis·H W ReesinkE E Reerink-Brongers
Jan 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·P Thomsen, P P Clausen
Sep 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·P P ClausenL R Mathiesen
Dec 1, 1981·Human Pathology·M J Phillips, S Poucell

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