HBV genotypes prevalence, precore and basal core mutants in Morocco

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Warda BahaAbdelouaheb Bennani

Abstract

The study of hepatitis B virus (HBV) genomic heterogeneity has become a major issue in investigations aimed at understanding the relationship between HBV mutants and the wide spectrum of clinical and pathological conditions associated with HBV infection. The objective of the current study was to find out the pattern of HBV genotypes circulating in Morocco and to investigate the precore (PC) and basal core promoter (BCP) mutants' status in Moroccan chronic hepatitis B patients. Viral genotypes were determined in 221 chronic carriers using INNO-LiPA HBV assay and hemi-nested PCR. Phylogenetic analysis was performed in 70 samples, and multiplex PCR method was used to confirm some genotyping results. PC and CP mutants were determined using Inno-Lipa. All isolates were successfully genotyped. The genotype distribution was D in 90.45% of cases, A (5.9%), E (1 case), and mixed genotypes (5 A/D and 2 D/F) in 3.17% patients. HBV carried in the HBV/D samples could be assigned to D7 (63.3%), D1 (32.7%) and 2% of strains to each D4 and D5, all HBV/A belonged to A2 subgenotype and HBV/E strain could not be sub-genotyped. In 70 studied strains, HBV mutants were detected in 88.6% of cases; PC mutants were detected in (40%) of patients and 21....Continue Reading

References

Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Rodriguez-FriasJ Guardia
Aug 7, 1998·Journal of Virological Methods·M LindhP Horal
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S LokP Andreone
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H KaoD S Chen
May 25, 2002·The Journal of General Virology·Karin Kidd-LjunggrenAlistair H Kidd
Jul 13, 2002·Journal of Medical Virology·Hideaki KatoMasashi Mizokami
Aug 29, 2002·The Journal of Infectious Diseases·Charles HannounUNKNOWN Interpred trial group
Mar 5, 2003·Seminars in Liver Disease·Stephen LocarniniAngeline Bartholomeusz
Dec 17, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oliver KirschbergStephan Schaefer
Jan 13, 2004·Reviews in Medical Virology·Angeline Bartholomeusz, Stephan Schaefer
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
May 26, 2004·Journal of Virological Methods·C ErogluA Sanic
Jan 9, 2007·World Journal of Gastroenterology : WJG·Stephan Schaefer
Sep 29, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Myron J TongWilliam G Corey
Jul 18, 2008·The Journal of General Virology·Tatjana TalloHeléne Norder
Jul 30, 2008·Journal of Virology·Fuat KurbanovMasashi Mizokami
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brian J McMahon

❮ Previous
Next ❯

Citations

May 17, 2014·World Journal of Gastroenterology : WJG·Mustafa Sunbul
Mar 28, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Sayeh EzzikouriSoumaya Benjelloun
Jul 23, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Joseph C ForbiYury E Khudyakov
Jul 20, 2014·Clinics and Research in Hepatology and Gastroenterology·Resat OzarasFehmi Tabak
Nov 2, 2018·Virus Genes·Wonderful T ChogaSimani Gaseitsiwe
Aug 12, 2016·Infectious Agents and Cancer·Wafaa Mohamed HusseinMeriem Khyatti
Feb 8, 2013·Anti-cancer Drugs·Yong-Song Guan, Qing He
Feb 27, 2017·Archives of Virology·Aïcha BensalemNabil Debzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.