HBV genotypic variability in Cuba

PloS One
C L LoureiroF H Pujol

Abstract

The genetic diversity of HBV in human population is often a reflection of its genetic admixture. The aim of this study was to explore the genotypic diversity of HBV in Cuba. The S genomic region of Cuban HBV isolates was sequenced and for selected isolates the complete genome or precore-core sequence was analyzed. The most frequent genotype was A (167/250, 67%), mainly A2 (149, 60%) but also A1 and one A4. A total of 77 isolates were classified as genotype D (31%), with co-circulation of several subgenotypes (56 D4, 2 D1, 5 D2, 7 D3/6 and 7 D7). Three isolates belonged to genotype E, two to H and one to B3. Complete genome sequence analysis of selected isolates confirmed the phylogenetic analysis performed with the S region. Mutations or polymorphisms in precore region were more common among genotype D compared to genotype A isolates. The HBV genotypic distribution in this Caribbean island correlates with the Y lineage genetic background of the population, where a European and African origin prevails. HBV genotypes E, B3 and H isolates might represent more recent introductions.

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Citations

Sep 22, 2019·Viruses·Barbara V LagoFrancisco C A Mello
Mar 7, 2020·The Journal of General Virology·Anna L McNaughtonM Azim Ansari
Apr 23, 2020·Scientific Reports·Livia Alves LimaAna Rita Coimbra Motta-Castro
Aug 24, 2020·Clinics and Research in Hepatology and Gastroenterology·Rayana Maryse ToyéCoumba Touré-Kane
Apr 4, 2021·Microorganisms·Rayana Maryse ToyéIsabelle Chemin
May 2, 2021·Journal of Viral Hepatitis·Jonas Michel WolfVagner Ricardo Lunge
May 24, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jonas Michel WolfVagner Ricardo Lunge

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Datasets Mentioned

BETA
KM606642-KM606972
AJ627226
AJ627219
KJ470898
AJ627223
AJ627226-AJ627228

Software Mentioned

BLAST
DNAman
Epi Info

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