HBV or HCV Coinfection in HIV-1-Infected Pregnant Women in France: Prevalence and Pregnancy Outcomes

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Valérie BenhammouANRS CO1/CO11-EPF French Perinatal Cohort study group

Abstract

Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is frequent in HIV-infected persons but their impact on pregnant HIV-infected women is understudied. We explored whether these coinfections are associated with adverse pregnancy outcomes and lower response to antiretroviral therapy (ART). Pregnancies in HIV-1-infected women included in the ANRS French Perinatal Cohort between 2005 and 2013 were analyzed if HBV and HCV infection statuses were available. Among 4236 women, the prevalence of HBV (HBs Ag+) and HCV (RNA+) were 6.2% (95% confidence interval: 5.4 to 6.8) and 1.7% (1.3 to 2.1), respectively. HCV coinfection was strongly associated with a history of drug use; HBV coinfection was 6 times more frequent in women born in Sub-Saharan Africa than in European France. Baseline HIV viral load, CD4 count, and HIV care during pregnancy were similar in coinfected and monoinfected HIV mothers, except that 90% of HBV/HIV women were receiving tenofovir and/or lamivudine or emtricitabine. HCV coinfection was significantly associated with cholestasis [adjusted odds ratio: 4.1 (1.5-10.8), P = 0.005], preterm delivery [3.0 (1.6-5.7), P < 0.001], lower CD4 [2.6 (1.0-6.4), P < 0.001], and detectable viral load [2.3 (1.0-5.5...Continue Reading

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Citations

Apr 3, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vani VannappagariUNKNOWN for APR and EPPICC
Apr 10, 2020·Expert Opinion on Drug Metabolism & Toxicology·Megan NearyAdeniyi Olagunju
Jan 18, 2019·Experimental and Therapeutic Medicine·Yuhong DongGuo Lei
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Oct 14, 2020·Nature Reviews. Gastroenterology & Hepatology·Norah A TerraultGonzague Jourdain
Oct 30, 2020·Journal of Virology·Anna ChudnovetsIrina Burd

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