PMID: 9537868Apr 16, 1998Paper

HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B

Journal of Hepatology
J VingerhoetsG Leroux-Roels

Abstract

Hepatitis B virus specific T cell responses are crucial for viral elimination but their nature is not fully understood. We studied the regulation of proliferation and cytokine production after antigenic stimulation in peripheral blood mononuclear cells from chronically HBV-infected patients and subjects with natural immunity after recovery from an acute infection. Proliferation and production of interferon-gamma, IL-10 and tumor necrosis factor-alpha were determined after stimulation with HBcAg, HBeAg or HBsAg in the absence or presence of IL-12 or neutralizing antibodies to IL-12, interferon-gamma, IL-4, IL-10 or tumor necrosis factor-alpha. Upon stimulation with HBcAg or HBeAg, peripheral blood mononuclear cells from chronic hepatitis B virus patients displayed a clear class-II restricted proliferative response (SI greater than 2.5). Both interferon-gamma (less than 50 IU/ml) and IL-10 levels up to 600 pg/ml were detected. Proliferative or cytokine responses to HBsAg were very weak or absent. Addition of IL-12 to HBeAg-stimulated cultures increased the production of interferon-gamma to more than 200 IU/ml in all patients and slightly increased the production of IL-10. Neutralization of IL-10 increased the HBeAg-induced interf...Continue Reading

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Citations

Mar 24, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tanju B OzkanSibel Aker
Oct 17, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fusun Zeynep AkcamHuseyin Vural
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T H Mogensen, S R Paludan
Nov 8, 2012·Hepatitis Research and Treatment·Sirous Tayebi, Ashraf Mohamadkhani
Jan 5, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mohammad K ArababadiDerek Kennedy
Apr 7, 2009·Cellular Immunology·Luisa BarbozaLisbeth Berrueta
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvina Laura MalmassariMarie-Louise Michel
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiroyasu ItoHisataka Moriwaki
Jun 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Björn FischlerCatharina Hultgren
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeroen N StoopHarry L A Janssen
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eirini I RigopoulouNikolai V Naoumov
Aug 30, 2016·World Journal of Gastroenterology : WJG·Mahmoud Fathy DondetiRoba Mohamed Talaat

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