HCC Immune Surveillance and Antiviral Therapy of Hepatitis C Virus Infection

Liver Cancer
Solomon Owusu SekyereHeiner Wedemeyer

Abstract

HCV clearance by current antiviral therapies improves clinical outcomes but falls short in eliminating the risk for hepatocellular carcinoma (HCC) emergence. As the HCC immune surveillance establishment is vital for the control of neoplastic development and growth, we investigated its correlation with on-/post-treatment HCC emergence, and further analyzed the influence of viral eradication on this setup in patients with HCV-related liver cirrhosis. PBMC isolated at baseline and longitudinally during therapy were analyzed for tumor-associated antigen (TAA)-specific CD8+ T cell responses against glypican-3 overlapping peptides in vitro using high-definition flow cytometry. Multianalyte profiling of fifty soluble inflammatory mediators (SIM) in the plasma was also performed using Luminex-based multiplex technology. Cirrhosis patients were characterized by an altered profile of distinct SIMs at baseline. At this time point, immune-surveilling T cells targeting specific HCC-associated antigens were readily detectable in HCV-free cirrhosis patients whilst being rather weak in such patients who further developed HCC upon virus eradication. Therapy-induced cure of HCV infection analogously reduced the strength of the prevailing HCC imm...Continue Reading

Citations

Jun 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elliot MerrittMarc Martínez-Llordella
Sep 1, 2020·Expert Review of Molecular Diagnostics·Steffen K MeurerRalf Weiskirchen
Dec 5, 2020·Journal of Hepatology·Francesco Negro
Nov 3, 2020·Frontiers in Immunology·Heiner WedemeyerNiklas K Björkström
Dec 23, 2020·United European Gastroenterology Journal·Solomon Owusu SekyereHeiner Wedemeyer
Apr 3, 2021·Journal of Experimental & Clinical Cancer Research : CR·Zhengyi CaoXiaowei Zhang

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