Abstract
To evaluate similarities and differences in HCV-1 subtypes 1a and 1b in the presenting clinical features and the response to peg-interferon and ribavirin (Peg/RIBA). A total of 1,233 naïve patients with HCV genotype-1 infection, 159 (13%) with subtype 1a and 1,074 (87%) with subtype 1b were treated with Peg-IFN/RIBA at 12 Italian centers. Covariates included in the logistic model were age, gender, BMI, serum alanine aminotransferase, serum gamma-glutamiltranspeptidase (γGT), platelets counts, liver fibrosis, the occurrence of type 2 diabetes, baseline viremia, and IL28B genotype. At multivariate analysis, baseline characteristics differentiating patients with HCV-1a versus HCV-1b were young age, male gender, no F4 fibrosis, and no diabetes. SVR was achieved by 37% of patients with subtype 1b and 45% of those with subtype 1a, a nonsignificant difference of 8% (p = 0.069). In patients with subtype 1a, predictors of SVR were IL28B CC (OR 5.78, CI 1.98-16.83), RVR (OR 4.18, CI 1.66-10.55), female gender (OR 2.83, CI 1.83-6.78), and HCVRNA (OR 0.55, CI 0.32-0.96). In patients with subtype 1b, the ranking of predictors was levels RVR (OR 6.49, CI 4.32-9.73), IL28B CC (OR 3.32, CI 2.15-4.58), γGT (OR 1.59, CI 0.14-2.22), HCVRNA (OR 0....Continue Reading
References
Jan 1, 1987·Epidemiologic Reviews·S Greenland
Oct 5, 2001·Lancet·M P MannsJ K Albrecht
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Sep 9, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter SimmondsAnders Widell
Oct 21, 2005·PharmacoEconomics·Maria ButiRafael Esteban
Apr 6, 2007·Gastroenterology·Christoph SarrazinStefan Zeuzem
Apr 25, 2007·Alimentary Pharmacology & Therapeutics·M SiminL L Gluud
Aug 8, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tara L KiefferStefan Zeuzem
Nov 15, 2008·Methods in Molecular Biology·Carla Kuiken, Peter Simmonds
Mar 11, 2009·Antimicrobial Agents and Chemotherapy·Matthew F McCownIsabel Nájera
Aug 10, 2010·Lancet·Paul Y KwoUNKNOWN SPRINT-1 investigators
Jan 26, 2011·Journal of Medical Virology·F NicotJ Izopet
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ingrid Imhof, Peter Simmonds
Jun 18, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Markus CornbergStefan Zeuzem
Jun 24, 2011·The New England Journal of Medicine·Ira M JacobsonUNKNOWN ADVANCE Study Team
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for Study of Liver Diseases
Sep 16, 2011·The New England Journal of Medicine·Kenneth E ShermanUNKNOWN ILLUMINATE Study Team
Feb 3, 2012·Alimentary Pharmacology & Therapeutics·P RamachandranJ F Dillon
Apr 25, 2012·The American Journal of Gastroenterology·Helen S YeeUNKNOWN National Hepatitis C Program Office
Sep 12, 2012·Digestion·A AmanzadaG Ramadori
Nov 20, 2012·BMC Gastroenterology·Adriano M PellicelliUNKNOWN CLEO Group
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·James E Everhart, Elizabeth C Wright
Aug 27, 2013·Journal of Hepatology·Angelo AndriulliTeresa Santantonio
Jun 24, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Angelo AndriulliUNKNOWN Collaborators
Citations
Mar 20, 2015·Hepatology International·Mohammed Eslam, Jacob George
Dec 23, 2016·Expert Review of Anti-infective Therapy·Carolina ScagnolariGuido Antonelli
Apr 13, 2017·Journal of Medical Virology·Xiaoyang JiaoChangwen Ke
Mar 27, 2018·Journal of Immunology Research·V S KichatovaM I Mikhailov
Jan 26, 2021·Journal of Gastroenterology and Hepatology·Fei KongJunqi Niu