Abstract
Two children who acquired hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) infection by mother-to-child transmission were monitored during interferon alfa-2b and ribavirin treatment. In Patient C1, CD4(+) T cell counts were within normal range and HIV-1 viral load was undetectable. HCV viral load declined slightly following treatment initiation while novel variants rapidly emerged, indicative of quasispecies diversification. In Patient C2, CD4(+) T cell counts were low and HIV-1 replication was not fully controlled by antiretroviral therapy. HCV viral load rose during treatment and a striking conservation of the variant spectrum was observed. In both cases, there was no decline in quasispecies complexity following treatment initiation and sustained virological response was not achieved. These results suggest that reduction in quasispecies complexity, which is observed in adult responders following interferon treatment, may be mechanistically unrelated with evolution of the variant profile and/or selective pressure exerted on HCV.
References
Feb 28, 1998·Nucleic Acids Research·J D ThompsonD G Higgins
Dec 24, 1998·AIDS·M JohnM A French
Mar 14, 2000·AIDS·A LandauM D Kazatchkine
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MartinoP Marcellin
Dec 26, 2001·Bioinformatics·S KumarM Nei
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Patrizia FarciRobert H Purcell
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johnson Y N LauZhi Hong
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellen M TedaldiUNKNOWN HIV Outpatient Study (HOPS) Investigators
Jun 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Henry PollackWilliam Borkowsky
Jul 30, 2004·The New England Journal of Medicine·Raymond T ChungUNKNOWN AIDS Clinical Trials Group A5071 Study Team
Sep 15, 2004·Journal of Clinical Microbiology·Sophie CanobioHugo Soudeyns
Oct 7, 2004·Archives of Pediatrics & Adolescent Medicine·Susan SchuvalUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 1028S Team
Dec 15, 2005·Journal of Hepatology·Miriam J Alter
Jan 28, 2006·The Lancet Infectious Diseases·Kirsty EnglandMarie-Louise Newell
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patrizia FarciPier-Angelo Tovo
Aug 15, 2006·Gut·M P MannsM Cornberg
Jan 16, 2007·Clinical Microbiology Reviews·Anette WohnslandChristoph Sarrazin
Mar 27, 2007·Journal of Viral Hepatitis·N J ShireK E Sherman
Jun 15, 2007·Infection·A Kowala-PiaskowskaI Mozer-Lisewska
Nov 16, 2007·The American Journal of the Medical Sciences·Ighovwerha OfotokunJeffrey L Lennox
Dec 8, 2007·Nature Medicine·Mansun LawDennis R Burton
Dec 25, 2007·Journal of Hepatology·Mark S Sulkowski
Apr 19, 2008·The Journal of Infectious Diseases·M DantaP Klenerman
Citations
Sep 16, 2010·Archives of Virology·Magdalena FiglerowiczMarek Figlerowicz
Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ying MaGeorge F Gao
Apr 27, 2012·Journal of Clinical Microbiology·Ariane LaroucheHugo Soudeyns
Dec 12, 2012·Viruses·Armelle Le CampionHugo Soudeyns
Aug 12, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sarah L Fishman, Andrea D Branch
Jun 1, 2010·Journal of Medical Virology·Raffaella RossoClaudio Viscoli
Oct 22, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alejandro Escobar-GutiérrezMayra Cruz-Rivera
Nov 10, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Paulina JackowiakMarek Figlerowicz
May 23, 2012·Virus Research·Paulina JackowiakMarek Figlerowicz
Nov 12, 2013·Virology·María Inés GismondiMaría Victoria Preciado
May 2, 2015·PloS One·Iwona Bukowska-OśkoTomasz Laskus
Sep 22, 2017·Journal of Virology·Sébastien Fauteux-DanielHugo Soudeyns
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hossein KeyvaniHamid Reza Mollaie
Jul 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Giuseppe IndolfiMassimo Resti