HCV-Related Rheumatic Manifestations and Therapeutic Strategies

Current Drug Targets
Marco SebastianiClodoveo Ferri

Abstract

A number of hepatic and extra-hepatic autoimmune disorders may complicate a percentage of patients with hepatitis C virus (HCV) infection that is both hepatotropic and lymphotropic agent; the resulting clinical phenotypes can be grouped into the so-called HCV syndrome. This latter includes various rheumatic disorders that are frequently characterized by clinical or serological overlap; thus, a correct patients' classification is necessary prior to decide the therapy. The management of these conditions is particularly difficult, given the coexistence of viral infection and immunological alterations. In this scenario, cryoglobulinemic vasculitis represents the prototype of HCV-related rheumatic disorders that can be treated at different levels by means of etiological (antivirals) and/or pathogenetic and/or symptomatic treatments (rituximab, cyclophosphamide, steroids, plasmapheresis, etc). In clinical practice, the therapeutic strategy should take into account the specific symptoms combination and the severity/activity of the disease, according to each patient's conditions. This review focuses on the clinico-diagnostic assessments and therapeutical approaches of some rheumatic disorders complicating HCV infection, mainly arthriti...Continue Reading

Citations

Nov 16, 2018·Clinical and Experimental Medicine·Franco DammaccoVito Racanelli
Dec 11, 2019·Current Pharmaceutical Design·Hsiuying Wang
Sep 6, 2019·Journal of Immunology Research·Silvia Martina FerrariAlessandro Antonelli

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