HCV response in patients with end stage renal disease treated with combination pegylated interferon alpha-2a and ribavirin.

Journal of Clinical Gastroenterology
Wyel HakimWajahat Mehal

Abstract

To determine the efficacy and safety of combination therapy in patients with hepatitis C virus (HCV) and end-stage renal disease (ESRD). There is little data on the treatment of ESRD patients with pegylated interferon and ribavirin. We designed a pilot study to determine the initial and 12-week posttreatment viral response. A nonrandomized, prospective observational study of adjusted-dose combination therapy. Twenty patients were enrolled and began pegylated interferon at 135 microg/wk SC, and 4 weeks later ribavirin was started at 200 mg PO weekly, increasing gradually to 3 times a week for a total of 48 weeks. Twenty patients: M:F 18:2; mean age 52.4 years; genotype 1: 18, non-genotype 1: 2. Of the 20 patients, 5 withdrew before starting treatment. Of the 11 patients who reached 3 months, 6 had early virologic response, defined as at least a 2-log drop in their HCV count (54.5%). Of the 5 patients who were treated for 1-year, only 1 patient had a response 12 weeks after treatment. Side effects included 4 cases of anemia and 1 patient with headache. The initial response rate in individuals taking 3 months of treatment in our study is comparable with studies in non-ESRD patients with no serious adverse side effects. However, th...Continue Reading

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Citations

Jan 26, 2011·Journal of Gastroenterology and Hepatology·Chen-Hua Liu, Jia-Horng Kao
Apr 13, 2011·Seminars in Dialysis·Andres F CarrionPaul Martin
Jul 21, 2012·Clinical and Experimental Nephrology·Şükran KöseGülsün Çavdar
Jul 5, 2013·Kidney International·Fabrizio FabriziPiergiorgio Messa
Dec 25, 2010·Pharmacotherapy·McKenzie C Ferguson
Jan 1, 2013·ISRN Nephrology·Fabrizio Fabrizi
Jul 15, 2011·International Journal of Nephrology·Marco CarboneJames Neuberger
Jul 4, 2015·The Annals of Pharmacotherapy·Kimberly A Toussaint-Miller, Jennifer Andres
Apr 14, 2010·Nature Reviews. Nephrology·Fabrizio FabriziPaul Martin
Apr 8, 2015·World Journal of Hepatology·Smaragdi MarinakiIoanna K Delladetsima
Nov 4, 2017·Journal of Clinical Gastroenterology·Veronica Angulo-DiazAnnMarie Liapakis
Jan 17, 2015·World Journal of Gastroenterology : WJG·Roberto J Carvalho-FilhoMaria Lucia G Ferraz
Aug 28, 2018·World Journal of Transplantation·Maurizio Salvadori, Aris Tsalouchos

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