HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum

PloS One
Yi TaoWanhua Shen

Abstract

In the developing central nervous system (CNS), progenitor cells differentiate into progeny to form functional neural circuits. Radial glial cells (RGs) are a transient progenitor cell type that is present during neurogenesis. It is thought that a combination of neural trophic factors, neurotransmitters and electrical activity regulates the proliferation and differentiation of RGs. However, it is less clear how epigenetic modulation changes RG proliferation. We sought to explore the effect of histone deacetylase (HDAC) activity on the proliferation of RGs in the visual optic tectum of Xenopus laevis. We found that the number of BrdU-labeled precursor cells along the ventricular layer of the tectum decrease developmentally from stage 46 to stage 49. The co-labeling of BrdU-positive cells with brain lipid-binding protein (BLBP), a radial glia marker, showed that the majority of BrdU-labeled cells along the tectal midline are RGs. BLBP-positive cells are also developmentally decreased with the maturation of the brain. Furthermore, HDAC1 expression is developmentally down-regulated in tectal cells, especially in the ventricular layer of the tectum. Pharmacological blockade of HDACs using Trichostatin A (TSA) or Valproic acid (VPA) ...Continue Reading

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Citations

Jan 23, 2016·Frontiers in Cellular Neuroscience·Xia GuoWanhua Shen
Apr 1, 2018·The Journal of Comparative Neurology·Gabriela Edwards-FaretJuan Larraín
Apr 4, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Juanmei GaoWanhua Shen
Mar 26, 2016·Developmental Neurobiology·Leah Herrgen, Colin J Akerman
Jan 27, 2020·Developmental Neuroscience·Santosh R D'Mello

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Methods Mentioned

BETA
histone acetylation
acetylation
confocal microscopy
light microscopy
fluorescence
transfection

Software Mentioned

Adobe Photoshop
iMaris

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