PMID: 24286308Nov 30, 2013Paper

HDAC3 acts as a negative regulator of angiogenesis

BMB Reports
Deokbum ParkDooil Jeoung

Abstract

Histone deacetylase-3 (HDAC3) is involved in cellular proliferation, apoptosis and transcriptional repression. However, the role of HDAC3 in angiogenesis remains unknown. HDAC3 negatively regulated the expression of angiogenic factors, such as VEGF and plasminogen activator inhibitor-1 (PAI-1). HDAC3 showed binding to promoter sequences of PAI-1. HDAC3 activity was necessary for the expression regulation of PAI-1 by HDAC3. VEGF decreased the expression of HDAC3, and the down-regulation of HDAC3 enhanced endothelial cell tube formation. HDAC3 negatively regulated tumor-induced angiogenic potential. We show the novel role of HDAC3 as a negative regulator of angiogenesis.

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Citations

Apr 11, 2014·Molecular Cancer·Lupeng LiJiping Zeng
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oskar CiesielskiAneta Balcerczyk
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Minjeong YeonDooil Jeoung
May 26, 2017·Molecules and Cells·Youngmi KimDooil Jeoung
Dec 26, 2018·International Journal of Molecular Sciences·Yoojung KwonDooil Jeoung
Dec 8, 2020·Frontiers in Cell and Developmental Biology·Xiaona ChenHong Li
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Minjeong YeonDooil Jeoung

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