HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

Frontiers in Cellular Neuroscience
Michal MielcarekFabien Guidez

Abstract

For the past decade protein acetylation has been shown to be a crucial post-transcriptional modification involved in the regulation of protein functions. Histone acetyltransferases (HATs) mediate acetylation of histones which results in the nucleosomal relaxation associated with gene expression. The reverse reaction, histone deacetylation, is mediated by histone deacetylases (HDACs) leading to chromatin condensation followed by transcriptional repression. HDACs are divided into distinct classes: I, IIa, IIb, III, and IV, on the basis of size and sequence homology, as well as formation of distinct repressor complexes. Implications of HDACs in many diseases, such as cancer, heart failure, and neurodegeneration, have identified these molecules as unique and attractive therapeutic targets. The emergence of HDAC4 among the members of class IIa family as a major player in synaptic plasticity raises important questions about its functions in the brain. The characterization of HDAC4 specific substrates and molecular partners in the brain will not only provide a better understanding of HDAC4 biological functions but also might help to develop new therapeutic strategies to target numerous malignancies. In this review we highlight and sum...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·V M RichonP A Marks
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M GrozingerS L Schreiber
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·C M Grozinger, S L Schreiber
Aug 16, 2001·Nucleic Acids Research·E A MiskaT Kouzarides
Nov 14, 2002·The Biochemical Journal·Annemieke J M de RuijterAndré B P van Kuilenburg
Feb 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emma HocklyGillian P Bates
Feb 19, 2003·The Journal of Biological Chemistry·Kevin PetrieArthur Zelent
Mar 19, 2003·Journal of Neurochemistry·Sangeeta ChawlaHilmar Bading
Apr 25, 2003·Trends in Genetics : TIG·Eric VerdinHerbert G Kasler
Apr 13, 2004·Molecular Biology of the Cell·Gabriela ParoniClaudio Brancolini
Oct 21, 2004·The Journal of Biological Chemistry·Gabriella GardianM Flint Beal
Sep 17, 2005·Cell Death and Differentiation·R N Saha, K Pahan
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy A Bolger, Tso-Pang Yao
Jan 18, 2006·Neuropathology and Applied Neurobiology·J Takahashi-FujigasakiH Fujigasaki
Sep 16, 2006·Neuropathology and Applied Neurobiology·J Takahashi-Fujigasaki, H Fujigasaki
Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cleo M Salisbury, Benjamin F Cravatt
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Liang GuoLin Chen
Apr 10, 2007·Journal of Molecular Neuroscience : MN·Ron S BroideChristopher J Winrow
Jul 20, 2007·Molecular and Cellular Biology·Gabriela ParoniClaudio Brancolini
Jul 25, 2007·The Journal of Biological Chemistry·Timothy A BolgerTso-Pang Yao
Oct 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·A LahmP Gallinari
Nov 30, 2007·Molecular Biology of the Cell·Gabriela ParoniClaudio Brancolini
May 24, 2008·Developmental Neurobiology·Nazanin MajdzadehSantosh R D'Mello
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·R B ParmigianiP A Marks
Jul 11, 2008·The Journal of Biological Chemistry·Matthew J BottomleyAndrea Carfí
Aug 12, 2008·Biochimica Et Biophysica Acta·Annamaria ScognamiglioLucia Altucci
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Rachel CoddAmalie A H Pakchung
Jan 10, 2009·Science·Bo Chen, Constance L Cepko
May 22, 2009·Journal of Cellular Biochemistry·P A Marks, W-S Xu
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark KilgoreGavin Rumbaugh
Dec 25, 2009·The Journal of Comparative Neurology·Michael J DarcyCharles C Ouimet
May 8, 2010·Current Opinion in Pharmacology·Maribel Parra, Eric Verdin
Oct 29, 2010·Trends in Pharmacological Sciences·André FischerLi-Huei Tsai
Dec 2, 2010·Molecular Biology of the Cell·Nadia CernottaClaudio Brancolini
Aug 23, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying-Jie GuanQian Chen
Nov 2, 2011·The Journal of Cell Biology·Johannes BacksEric N Olson
Jun 5, 2012·Molecular Cell·Moon-Chang ChoiTso-Pang Yao
Jun 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nassila AkchicheJean-Luc Daval
Jul 17, 2012·Human Molecular Genetics·Katherine V BriccenoBarrington G Burnett

❮ Previous
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Citations

Jan 29, 2016·ACS Medicinal Chemistry Letters·Christopher A LuckhurstCelia Dominguez
Feb 24, 2016·Drug Development Research·Walter H MoosKosta Steliou
Dec 25, 2015·Biochemical and Biophysical Research Communications·Satoshi KameshimaHideyuki Yamawaki
Oct 16, 2015·Rare Diseases·Michal Mielcarek
Mar 13, 2016·Neurobiology of Disease·Hui YuanJun Li
Aug 10, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sorabh Sharma, Rajeev Taliyan
Jan 22, 2017·Journal of Pineal Research·Juan C MayoRussel J Reiter
Dec 7, 2016·Chemistry : a European Journal·Christian MeynersFranz-Josef Meyer-Almes
Nov 28, 2018·Chemical Biology & Drug Design·Franz-Josef Meyer-Almes
Feb 12, 2019·Molecular Psychiatry·Mari Sild, Linda Booij
Dec 17, 2015·Clinical and Translational Medicine·Michal Mielcarek, Mark Isalan
Apr 11, 2019·Molecular Genetics & Genomic Medicine·Maolian GongKlemens Raile
May 10, 2019·International Journal of Molecular Sciences·Debarati BanikAlejandro Villagra
Jul 13, 2019·Neurotoxicity Research·Sachchida Nand RaiSurya Pratap Singh
Nov 2, 2017·Journal of Cellular Biochemistry·Fei HouQingsheng Kong
Aug 21, 2020·Expert Opinion on Investigational Drugs·Fanni Boros, László Vécsei
Dec 14, 2018·International Journal of Molecular Sciences·Jingjing RenChris M Reilly
Jun 8, 2018·Frontiers in Physiology·Bethan J CritchleyMichal Mielcarek
Nov 13, 2018·World Journal of Gastroenterology : WJG·Dimitrios SchizasDimitrios Moris
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anastasia RicciMichele Menotta
Feb 13, 2020·International Journal of Molecular Sciences·Baruh PolisAbraham O Samson
Jan 8, 2020·International Journal of Molecular Sciences·Shana V StoddardDavita L Watkins
Apr 17, 2021·Frontiers in Molecular Neuroscience·Patrick MainHelen L Fitzsimons
Jul 17, 2019·Current Medicinal Chemistry·Dimitrios SchizasDimitrios Moris

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Methods Mentioned

BETA
ubiquitination
SMA
acetylation
histone acetylation

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