HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

Skeletal Muscle
Eva PignaSergio Adamo

Abstract

Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy. Histone deacetylase 4 (HDAC4) mediates skeletal muscle response to denervation, suggesting the use of HDAC inhibitors as a therapeutic approach to neurogenic muscle atrophy. However, the effects of HDAC4 inhibition in skeletal muscle in response to long-term denervation have not been described yet. To further study HDAC4 functions in response to denervation, we analyzed mutant mice in which HDAC4 is specifically deleted in skeletal muscle. After an initial phase of resistance to neurogenic muscle atrophy, skeletal muscle with a deletion of HDAC4 lost structural integrity after 4 weeks of denervation. Deletion of HDAC4 impaired the activation of the ubiquitin-proteasome system, delayed the autophagic response, and dampened the OS response in skeletal muscle. Inhibition of the ubiquitin-proteasome system or the autophagic response, if on the one hand, conferred resistance to neurogenic muscle atrophy; on the other hand, induced loss of muscle integrity and inflammation in mice lacking HDAC4 in skeletal muscle. Moreover, treatment with the antioxidant drug...Continue Reading

References

Oct 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T W WuR D Weisel
Sep 15, 1996·Archives of Biochemistry and Biophysics·M G Salgo, W A Pryor
Dec 29, 1998·The Journal of Cell Biology·J A JohnstonR R Kopito
Apr 30, 2003·The Journal of Biological Chemistry·Julie L WebbDavid C Rubinsztein
Aug 21, 2003·Trends in Molecular Medicine·David J Glass
Oct 8, 2004·Pediatric Research·James K FrielL Jackson Roberts
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Scott K PowersKeith C DeRuisseau
Mar 15, 2005·Experimental Gerontology·Stefania FulleGiorgio Fanò
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paolo E ForniCarola Ponzetto
Dec 26, 2006·FEBS Letters·M Lamar SeibenhenerMarie W Wooten
Jan 11, 2007·The Journal of Biological Chemistry·Helen L Eley, Michael J Tisdale
Jun 15, 2007·British Journal of Haematology·Orciuolo EnricoPetrini Mario
Jun 21, 2007·The Journal of Biological Chemistry·Serhiy PankivTerje Johansen
Jun 23, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Florian L MullerHolly Van Remmen
Sep 6, 2007·The Journal of Clinical Investigation·Matthew J PotthoffEric N Olson
Sep 18, 2007·The Journal of Biological Chemistry·Todd J CohenTso-Pang Yao
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Jul 26, 2008·Journal of Cell Science·Elena ShvetsZvulun Elazar
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Dec 3, 2008·Cell Metabolism·Gabriella DobrowolnyAntonio Musarò
Dec 23, 2008·Autophagy·Michael F N O'Leary, David A Hood
Mar 3, 2009·Molecular Cell·Vladimir KirkinTerje Johansen
Apr 21, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·G S SupinskiL A Callahan
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsuko Yoshioka HigashiMotoko Yanagita
Apr 23, 2009·Journal of Neurochemistry·Sebastian Lunke, Assam El-Osta
Dec 1, 2009·Cell Metabolism·Eva MasieroMarco Sandri
Feb 4, 2010·PLoS Biology·Derek P NarendraRichard J Youle
Feb 6, 2010·FEBS Letters·Marco Sandri
Jul 27, 2010·Autophagy·Jeong-Sun JuConrad C Weihl
Apr 5, 2011·Muscle & Nerve·Cecile JamartMarc Francaux
May 3, 2011·Free Radical Biology & Medicine·Fu Shang, Allen Taylor
May 21, 2011·Autophagy·Jaclyn Nicole Le GrandMichaël Boyer-Guittaut
Aug 17, 2011·BMC Musculoskeletal Disorders·Annabelle Z CaronGuillaume Grenier
Jan 1, 1990·International Journal of Immunopathology and Pharmacology·R MancinelliTiziana Pietrangelo
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Viviana MoresiEric N Olson

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Citations

Jan 10, 2019·American Journal of Physiology. Cell Physiology·Haiming Liu, LaDora V Thompson
Jul 7, 2019·Acta Neuropathologica Communications·Elisabeth RossaertLudo Van Den Bosch
Nov 17, 2019·International Journal of Molecular Sciences·Sarassunta UcciCecilia Verga-Falzacappa
Mar 4, 2020·International Journal of Molecular Sciences·Keisuke HitachiKunihiro Tsuchida
Apr 3, 2020·Journal of Cachexia, Sarcopenia and Muscle·Andrew P KoutnikDominic P D'Agostino
Jun 21, 2020·The FEBS Journal·Erica HurtadoMònica Suelves
Jul 20, 2019·Nature Communications·Perrine CastetsMarkus A Rüegg
Oct 16, 2018·Frontiers in Physiology·Alessandra RenziniSergio Adamo
Jan 28, 2021·Cells·Maria-Letizia CampanariEdor Kabashi
May 7, 2020·Redox Biology·M C Gomez-CabreraJ Viña
Feb 22, 2021·Ageing Research Reviews·Osvaldo DelbonoMaria Laura Messi
May 8, 2020·Neurobiology of Disease·Annis-Rayan BourefisEdor Kabashi
Jun 3, 2021·International Journal of Molecular Sciences·Shawna L McMillinCarol A Witczak

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Methods Mentioned

BETA
PCR
Assay
transfection
acetylation

Software Mentioned

ImageJ
VassarStats

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