HDAC4 regulates muscle fiber type-specific gene expression programs

Molecules and Cells
Todd J CohenTso-Pang Yao

Abstract

Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative-fibers. Genetic reprogramming of fast/glycolytic fibers to oxidative fibers by active CaMKII or calcineurin leads to increased HDAC4 phosphorylation, HDAC4 nuclear export, and an increase in markers associated with oxidative fibers. Indeed, HDAC4 represses the MEF2-dependent, PGC-1α-mediated oxidative metabolic gene program. Thus differential phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs.

References

May 1, 1990·Journal of Applied Physiology·D P FitzsimonsK M Baldwin
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Feb 15, 2000·The Journal of Biological Chemistry·F J NayaE N Olson
Feb 14, 2002·Trends in Biochemical Sciences·Timothy A McKinseyEric N Olson
Apr 16, 2002·Science·Hai WuR Sanders Williams
Aug 7, 2002·Biochemical and Biophysical Research Communications·Shin TeradaIzumi Tabata
Nov 22, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Dirk Pette
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael P CzubrytEric N Olson
Jul 17, 2003·Acta Physiologica Scandinavica·E E Spangenburg, F W Booth
May 27, 2004·Diabetes·Patrick Schrauwen, Matthijs K C Hesselink
Jul 2, 2004·American Journal of Physiology. Cell Physiology·Takayuki AkimotoZhen Yan
Jun 8, 2006·Annual Review of Biochemistry·Rhonda Bassel-Duby, Eric N Olson
Jun 13, 2006·The Journal of Clinical Investigation·Johannes BacksEric N Olson
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marco SandriBruce M Spiegelman
Sep 6, 2007·The Journal of Clinical Investigation·Matthew J PotthoffEric N Olson
Sep 18, 2007·The Journal of Biological Chemistry·Todd J CohenTso-Pang Yao
Sep 19, 2007·Molecular and Cellular Biology·Matthew J PotthoffEric N Olson
Sep 11, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Todd J CohenTso-Pang Yao
Jun 5, 2012·Molecular Cell·Moon-Chang ChoiTso-Pang Yao

❮ Previous
Next ❯

Citations

Feb 2, 2016·Biochemical and Biophysical Research Communications·Ana SierraLeonid V Zingman
Sep 27, 2016·Scientific Reports·Jin Rong OwReshma Taneja
Apr 14, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alec I M Simmonds, Frank Seebacher
Jul 8, 2018·The Journal of Experimental Biology·Jason TallisFrank Seebacher
Jun 27, 2015·Journal of Applied Physiology·Sylvie Dupré-AucouturierDominique Desplanches
May 21, 2019·Oncotarget·Kiran MadugulaPooja Jain
Jun 5, 2019·Scientific Reports·Frank Seebacher, Alec I M Simmonds
Oct 3, 2018·International Journal of Oncology·Jun-Yan CaiXue-Jun Ni
Jun 21, 2020·The FEBS Journal·Erica HurtadoMònica Suelves
Sep 20, 2020·Scandinavian Journal of Medicine & Science in Sports·Miriam Martinez-CantonJose A L Calbet
Mar 23, 2020·Tissue Engineering and Regenerative Medicine·Megan E KondashGeorge A Truskey
Jan 18, 2020·Animals : an Open Access Journal From MDPI·Jing ZhaoHuadong Yin
Nov 15, 2018·International Journal of Molecular Sciences·Natalia A VilchinskayaBoris S Shenkman
May 3, 2019·Journal of Neuroscience Research·María F Harman, Mauricio G Martín
Feb 7, 2018·Chemical Reviews·Ibraheem AliMelanie Ott

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Cell Fate Conversion By mRNA

mRNA-based technology is being studied as a potential technology that could be used to reprogram cell fate. This technique provides the potential to generate safe reprogrammed cells that can be used for clinical applications. Here is the latest research on cell fate conversion by mRNA.