HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation

Oncotarget
Rui YangHongjuan Cui

Abstract

Histone deacetylase 9 (HDAC9), a member of class II HDACs, regulates a wide variety of normal and abnormal physiological functions. We found that HDAC9 is over-expressed in prognostically poor glioblastoma patients. Knockdown HDAC9 decreased proliferation in vitro and tumor formation in vivo. HDAC9 accelerated cell cycle in part by potentiating the EGFR signaling pathway. Also, HDAC9 interacted with TAZ, a key downstream effector of Hippo pathway. Knockdown of HDAC9 decreased the expression of TAZ. We found that overexpressed TAZ in HDAC9-knockdown cells abrogated the effects induced by HDAC9 silencing both in vitro and in vivo. We demonstrated that HDAC9 promotes tumor formation of glioblastoma via TAZ-mediated EGFR pathway activation, and provide the evidence for promising target for the treatment of glioblastoma.

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Citations

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Methods Mentioned

BETA
xenograft
xenografts
flow cytometry
immunoprecipitation
PCR
Co-immunoprecipitation
FACS
acetylation

Software Mentioned

GraphPad Prism
R2
CellQuest

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