HDL abnormalities in familial hypercholesterolemia: Focus on biological functions

Progress in Lipid Research
Shiva GanjaliAmirhossein Sahebkar

Abstract

Although a selective strong elevation in the plasma level of low-density lipoprotein (LDL) cholesterol is the hallmark of familial hypercholesterolemia (FH), also other plasma lipoprotein and lipid subspecies are changed in these patients. Several studies in FH patients have pointed to the qualitative abnormalities of high-density lipoprotein (HDL) particles, including their triglyceride and sphingomyelin enrichment, reduced capacity to promote cholesterol efflux from macrophages, impaired anti-inflammatory and anti-oxidant activities, and reduced plasma levels of miRs regulating HDL-dependent cholesterol efflux from macrophage foam cells, typical of atherosclerotic lesions. Thus, accurate understanding of HDL functionality and its disturbances in FH may serve a better estimation of the prognosis and also provide additional clues when searching for novel therapeutic choices in this disease. In spite of such a potential promise, there has been no prior comprehensive review focusing on indices of HDL function in FH patients. In the present review, we aim to fulfill this gap by identifying measures of HDL function that are impaired in FH, and by providing a concise summary on the impact of different lipid-modifying therapies on HD...Continue Reading

Citations

Jan 13, 2018·Journal of Cellular Physiology·Hamid MollazadehAmirhossein Sahebkar
Aug 5, 2018·Journal of Cellular Physiology·Shiva GanjaliAmirhossein Sahebkar
Feb 3, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Maria Donata Di TarantoGiuliana Fortunato
Jun 1, 2018·Current Medicinal Chemistry·Angela PirilloGiuseppe Danilo Norata
Jul 14, 2019·BioFactors·Afsane BahramiAmirhossein Sahebkar
Jan 16, 2018·Expert Opinion on Pharmacotherapy·Niki KatsikiAmirhossein Sahebkar
Jul 11, 2019·IUBMB Life·Susan SarhadiAmirhossein Sahebkar
Mar 7, 2021·Journal of Lipid Research·Kévin ChemelloDirk Blom
Jun 13, 2020·Seminars in Arthritis and Rheumatism·Shiva GanjaliAmirhossein Sahebkar
Mar 25, 2020·Trends in Cardiovascular Medicine·Vanessa BianconiUNKNOWN International Lipid Expert Panel (ILEP)
May 14, 2021·Current Atherosclerosis Reports·Kasey C Vickers, Danielle L Michell
Oct 20, 2020·The American Journal of Emergency Medicine·Akkan AvciSalim Satar
Aug 7, 2021·Biomedicines·Juan Pedro-BotetDavid Benaiges

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