Jan 19, 2010

HDL and CETP in atherogenesis

Deutsche medizinische Wochenschrift
J PössUlrich Laufs

Abstract

Despite optimal treatment of high low density lipoprotein (LDL) cholesterol with statins many cardiovascular events are not prevented. Additional therapeutic strategies are required to reduce the residual cardiovascular risk. Large epidemiological studies show an inverse correlation between the plasma concentration of high density lipoprotein (HDL) cholesterol and the incidence of cardiovascular events. Under physiological conditions, HDL is vasculoprotective and mediates the reverse cholesterol transport. However, new studies suggest that HDL particles represent a heterogeneous population. Under several pathophysiological conditions, HDL was shown to promote atherogenesis and inflammation. Interventional studies and metaanalyses examining the effect of increasing HDL cholesterol have reported mixed results. Inhibition of cholesteryl ester transfer protein (CETP) is a new and potent strategy to increase HDL concentrations. However, the first CETP-inhibitor torcetrapib increased blood-pressure and increased cardiovascular events despite increasing HDL. The blood-pressure increasing effects are not known for more recently developed CETP inhibitors such as dalcetrapib and anacetrapib nor in patients with genetic CETP deficiency. A...Continue Reading

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Mentioned in this Paper

Hyperalphalipoproteinemia 1
CETP protein, human
Coronary Artery Disease
Quinolines
Reverse Cholesterol Transport
Serum HDL Cholesterol Measurement
CETP wt Allele
Sulfhydryl Compounds
CETP gene
Atherogenesis

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