HDL and electronegative LDL exchange anti- and pro-inflammatory properties.

Journal of Lipid Research
Cristina BancellsSonia Benitez

Abstract

Electronegative LDL [LDL(-)] is a minor modified LDL subfraction present in blood with inflammatory effects. One of the antiatherogenic properties of HDL is the inhibition of the deleterious effects of in vitro modified LDL. However, the effect of HDL on the inflammatory activity of LDL(-) isolated from plasma is unknown. We aimed to assess the putative protective role of HDL against the cytokine released induced in monocytes by LDL(-). Our results showed that LDL(-) cytokine release was inhibited when LDL(-) was coincubated with HDL and human monocytes and also when LDL(-) was preincubated with HDL and reisolated prior to cell incubation. The addition of apoliprotein (apo)AI instead of HDL reproduced the protective behavior of HDL. HDL preincubated with LDL(-) promoted greater cytokine release than native HDL. Incubation of LDL(-) with HDL decreased the electronegative charge, phospholipase C-like activity, susceptibility to aggregation and nonesterified fatty acid (NEFA) content of LDL(-), whereas these properties increased in HDL. NEFA content in LDL appeared to be related to cytokine production because NEFA-enriched LDL induced cytokine release. HDL, at least in part through apoAI, inhibits phospholipase-C activity and cyto...Continue Reading

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Citations

May 4, 2011·Current Opinion in Lipidology·Bela F AsztalosErnst J Schaefer
Sep 26, 2013·Mediators of Inflammation·Montserrat EstruchSònia Benítez
Mar 19, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Montserrat EstruchSonia Benítez
Jan 1, 2011·Pure and Applied Chemistry. Chimie Pure Et Appliquée·Liang-Yin KeChu-Huang Chen
Jul 25, 2013·Atherosclerosis·Montserrat EstruchSonia Benitez
Jun 1, 2018·Current Medicinal Chemistry·Angela PirilloGiuseppe Danilo Norata
May 1, 2021·Journal of Clinical Medicine·Idoia GenuaJosé Luis Sánchez-Quesada
May 12, 2021·Nature Reviews. Nephrology·Heidi NoelsJoachim Jankowski

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