HDL Cholesterol Efflux Predicts Graft Failure in Renal Transplant Recipients

Journal of the American Society of Nephrology : JASN
Wijtske AnnemaUwe J F Tietge

Abstract

High-density lipoprotein (HDL) particles are involved in the protection against cardiovascular disease by promoting cholesterol efflux, in which accumulated cholesterol is removed from macrophage foam cells. We investigated whether HDL cholesterol efflux capacity is associated with cardiovascular mortality, all-cause mortality, and graft failure in a cohort of renal transplant recipients (n=495, median follow-up 7.0 years). Cholesterol efflux capacity at baseline was quantified using incubation of human macrophage foam cells with apolipoprotein B-depleted plasma. Baseline efflux capacity was not different in deceased patients and survivors (P=0.60 or P=0.50 for cardiovascular or all-cause mortality, respectively), whereas recipients developing graft failure had lower efflux capacity than those with functioning grafts (P<0.001). Kaplan-Meier analysis demonstrated a lower risk for graft failure (P=0.004) but not cardiovascular (P=0.30) or all-cause mortality (P=0.31) with increasing gender-stratified tertiles of efflux capacity. Cox regression analyses adjusted for age and gender showed that efflux capacity was not associated with cardiovascular mortality (hazard ratio [HR], 0.89; 95% confidence interval [95% CI], 0.67 to 1.19; P...Continue Reading

Associated Clinical Trials

References

Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·G W CockerillP J Barter
May 1, 1997·Kidney International·K SolezL D Truong
Sep 1, 1999·Kidney International·L C Paul
Mar 4, 2000·The New England Journal of Medicine·S HariharanD Stablein
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Herwig-Ulf Meier-KriescheBruce Kaplan
Sep 18, 2004·Annals of the Rheumatic Diseases·K de LeeuwM Bijl
Jun 25, 2005·Circulation Research·Gary F Lewis, Daniel J Rader
Aug 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rutger M van ReeStephan J L Bakker
Mar 15, 2006·Transplantation·Brian J Nankivell, Jeremy R Chapman
Dec 2, 2006·Transplant Immunology·P J Yates, M L Nicholson
Apr 14, 2007·Circulation Research·Richard N Mitchell, Peter Libby
Jul 11, 2007·Current Opinion in Lipidology·Benjamin J AnsellAlan M Fogelman
Nov 7, 2007·The New England Journal of Medicine·Philip J BarterUNKNOWN ILLUMINATE Investigators
Jan 10, 2008·Diabetes Care·UNKNOWN American Diabetes Association
Apr 4, 2008·Journal of Atherosclerosis and Thrombosis·Dmitri SviridovPaul Nestel
Nov 13, 2008·Contributions to Nephrology·Robert B Colvin
Dec 3, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D M ZelleS J L Bakker
Apr 27, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K IsraniUNKNOWN PORT Investigators
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Oct 1, 2011·European Journal of Clinical Investigation·Paul J W H KappelleUwe J F Tietge
Oct 18, 2011·Lancet·Alan G JardineHallvard Holdaas
Nov 8, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S J SinkelerS J L Bakker
Nov 17, 2011·The New England Journal of Medicine·William E BodenWilliam Weintraub
Nov 24, 2011·Transplant Immunology·Olivier Thaunat
Mar 31, 2012·Nutrition & Metabolism·Wijtske Annema, Uwe Jf Tietge
Nov 7, 2012·The New England Journal of Medicine·Gregory G SchwartzUNKNOWN dal-OUTCOMES Investigators
Mar 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Xin-Min LiStanley L Hazen
May 27, 2014·Lancet·Alberto OrtizUNKNOWN Board of the EURECA-m Working Group of ERA-EDTA
Jul 30, 2014·Journal of the American Society of Nephrology : JASN·Chantal KopeckyMarcus D Säemann
Nov 19, 2014·The New England Journal of Medicine·Anand RohatgiPhilip W Shaul

❮ Previous
Next ❯

Citations

Sep 1, 2015·Journal of the American Society of Nephrology : JASN·Valentina Kon, MacRae F Linton
Mar 15, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Wijtske Annema, Arnold von Eckardstein
Sep 11, 2016·Journal of the American Society of Nephrology : JASN·Chantal KopeckyUwe J F Tietge
Jan 15, 2017·Molecular Nutrition & Food Research·Rima H MistryUwe J F Tietge
Jan 19, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Tae Ik ChangHamid Moradi
Feb 24, 2018·Journal of the American Society of Nephrology : JASN·Florian Kronenberg
Jul 19, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Sanam EbtehajUwe J F Tietge
Nov 28, 2019·Journal of Clinical Medicine·Tomás A GacitúaStephan J L Bakker
Mar 24, 2016·Current Opinion in Nephrology and Hypertension·Haichun YangValentina Kon
Apr 26, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yohei TsuchidaValentina Kon
Sep 19, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Camilo G SotomayorStephan J L Bakker
Apr 1, 2016·Current Opinion in Lipidology·Arnold von Eckardstein, Lucia Rohrer
Aug 31, 2016·European Journal of Clinical Investigation·Rosa María AgraJohn P H Wilding
Jan 18, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Sangita Sudharshan, Ali Javaheri
May 1, 2018·Seminars in Dialysis·Hamid MoradiNosratola D Vaziri
Aug 31, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Camilo G SotomayorStephan J L Bakker
Aug 8, 2020·The Journal of Clinical Endocrinology and Metabolism·Trynke van der BoomRobin P F Dullaart
Jan 5, 2021·European Heart Journal·Thimoteus SpeerDanilo Fliser
Sep 15, 2019·International Journal of Cardiology·Yasunori SuematsuShin-Ichiro Miura
Dec 15, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Josephine L C AndersonUwe J F Tietge
Feb 17, 2021·Journal of Clinical Lipidology·Josephine L C AndersonUwe J F Tietge
Jan 11, 2020·Metabolism: Clinical and Experimental·Anouar HafianeMiguel A Frias
Mar 17, 2021·Clinical Chemistry·Sanna KuusistoMika Ala-Korpela
Apr 28, 2018·Journal of Clinical Lipidology·Sankar D NavaneethanJoseph V Nally
Aug 8, 2021·International Journal of Molecular Sciences·Valentina KonMacRae F Linton
Aug 8, 2021·Journal of Clinical Medicine·Josephine L C AndersonUwe J F Tietge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Journal of the American Society of Nephrology : JASN
Roland E SchmiederONTARGET Investigators
Clinical Journal of the American Society of Nephrology : CJASN
Tae Ik ChangEa Wha Kang
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Hamid MoradiK Kalantar-Zadeh
© 2021 Meta ULC. All rights reserved