HDL-cholesterol level provides additional prognosis in acute coronary syndromes

International Journal of Cardiology
Luís C L CorreiaJ Péricles Esteves

Abstract

In the setting of acute coronary syndromes, plasma lipids have not been defined as prognostic variables, however little research has been dedicated to this specific issue. In order to test the independent predictive value for in-hospital events of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglycerides measured at hospital admission, 97 individuals with unstable angina or non-ST-elevation acute myocardial infarction were evaluated. In-hospital events, defined as death, non-fatal myocardial infarction or recurrent unstable angina, were significantly predicted by HDL-cholesterol (C-statistics=0.69; 95% CI=0.55-0.83, P=0.018), contrary to LDL-cholesterol (C-statistics=0.40; 95% CI=0.24-0.56, P=0.23) and triglycerides (C-statistics=0.48; 95% CI=0.31-0.65, P=0.83). The best HDL-cholesterol cut-off point was 32 mg/dl, with a 33% incidence of events in patients with HDL-cholesterol < or =32 mg/dl, compared with only 9% in those with HDL-cholesterol>32 mg/dl (P=0.003). Logistic regression analysis showed HDL-cholesterol< or =32 mg/dl (OR=3.6; 95% CI=1.0-14; P=0.05) and TIMI Risk Score (OR=2.3; 95% CI=1.4-2.9, P=0.001) as the independent predictors of events. Furthermore, the addition of H...Continue Reading

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Citations

Nov 5, 2015·Heart, Lung & Circulation·Mehmet Baran KarataşOsman Bolca
Dec 15, 2010·Journal of the American College of Cardiology·Robert P Giugliano, Eugene Braunwald
Mar 3, 2015·The American Journal of Cardiology·Vanessa S ReddyUNKNOWN Investigators of National Registry of Myocardial Infarction (NRMI) 4b–5
Oct 12, 2011·Journal of Cardiovascular Medicine·Gian Francesco MuredduLeonardo De Luca

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