Abstract
High density lipoprotein (HDL) is important for defense against sepsis but becomes dysfunctional (Dys-HDL) during inflammation. We hypothesize that Dys-HDL correlates with organ dysfunction (sequential organ failure assessment (SOFA) score) early sepsis. A prospective cohort study of adult ED sepsis patients enrolled within 24 hours. Eighty eight patients were analyzed. Dys-HDL (expressed as HDL inflammatory index (HII)) correlated with SOFA at enrollment (r = 0.23, p = 0.024) and at 48 hours (r = 0.24, p = 0.026) but HII change over the first 48 hours did not correlate with change in SOFA (r = 0.06, p = 0.56). Enrollment HII was significantly different in patients with most severe organ failure (2.31, IQR 1.33-5.2) compared to less severe organ failure (1.81, IQR 1.23-2.64, p = 0.043). Change in HII over 48 hours was significantly different for in-hospital non-survivors (-0.45, IQR-2.6, -0.14 p = 0.015) and for 28-day non-survivors (-1.12, IQR -1.52, 0.12, p = 0.044). In a multivariable linear regression equation (R2 = 0.13), for each unit HII increase, 48-hour SOFA increased by 0.72 (p = 0.009). HII correlated with SOFA and predicted 48-hour SOFA score in early sepsis. Future studies are needed to delineate potential mechanis...Continue Reading
References
Nov 14, 1986·Biochimica Et Biophysica Acta·W H DaerrH Greten
May 20, 1993·The New England Journal of Medicine·J E Parrillo
May 22, 1997·Nature·K F KozarskyM Krieger
Nov 24, 1999·The Journal of Biological Chemistry·R L KitchensR S Munford
May 29, 2003·Critical Care Medicine·Henk J van LeeuwenKok P M van Kessel
Sep 10, 2003·Journal of Leukocyte Biology·B BeutlerR J Ulevitch
Apr 23, 2004·Journal of Lipid Research·Weerapan KhovidhunkitCarl Grunfeld
Aug 13, 2005·Critical Care Medicine·Jung-Yien ChienPan-Chyr Yang
Apr 9, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew J MurphyJaye P F Chin-Dusting
Nov 22, 2011·Journal of Gastroenterology and Hepatology·Yuyang ChenXiong Z Ruan
Dec 22, 2011·JAMA : the Journal of the American Medical Association·Jonathan S BoomerRichard S Hotchkiss
Jun 15, 2012·The Journal of Trauma and Acute Care Surgery·Woon Yong KwonKyuseok Kim
May 22, 2013·PloS One·Oleg F SharifovHimanshu Gupta
Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Jan 15, 2014·Critical Care Medicine·Laurent LagrostClaire Bonithon-Kopp
Mar 8, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Ling GuoXiang-An Li
Mar 22, 2014·Inflammation·Oleg F SharifovHimanshu Gupta
Jun 12, 2014·PloS One·Andrew H WaltonRichard S Hotchkiss
Jun 18, 2014·Cardiovascular Research·Alberico Luigi CatapanoGiuseppe Danilo Norata
Jul 12, 2014·Journal of Critical Care·I IliasI Dimopoulou
Oct 17, 2014·Science Translational Medicine·Keith R WalleyJohn H Boyd
Feb 24, 2015·Journal of Critical Care·Yu-Fen ChienChong-Jen Yu
Jan 13, 2016·Journal of Innate Immunity·John H BoydKeith R Walley
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
May 14, 2016·PloS One·Elena TopchiyKeith R Walley
Dec 25, 2016·Critical Care : the Official Journal of the Critical Care Forum·Faheem W GuirgisHenry E Wang
Feb 17, 2017·PloS One·Timo PaavolaTuire Salonurmi
Apr 30, 2017·Shock·Faheem W GuirgisFrederick A Moore
Aug 24, 2017·Journal of Lipid Research·Francesca ZimettiGraziana Lupattelli
Citations
Feb 7, 2019·PloS One·Kellie A MitchellHenry E Wang
Jan 17, 2019·Current Opinion in Lipidology·Mark TrinderLiam R Brunham
Oct 3, 2019·Current Opinion in Lipidology·Fabrizia BonacinaGiuseppe D Norata
Sep 21, 2019·BMJ Open·Faheem W GuirgisFrederick A Moore
Jun 25, 2020·Journal of Intensive Care Medicine·Lauren Page BlackFaheem W Guirgis
Jul 26, 2019·Clinical Proteomics·Narendra Kumar SharmaReinaldo Salomao
Jan 21, 2021·Annals of Intensive Care·Sébastien TanakaPhilippe Montravers
Jan 5, 2021·Journal of the American College of Emergency Physicians Open·Faheem W GuirgisFrederick Moore
Nov 10, 2020·Journal of Psoriasis and Psoriatic Arthritis·Alexander V SorokinNehal N Mehta
Mar 4, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisMichael Maes
Apr 4, 2021·Antioxidants·Alain MenzelTorsten Bohn
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra ZeljkovicBratislav Trifunovic
May 1, 2021·Journal of Clinical Medicine·Grant BarkerFaheem W Guirgis
May 22, 2021·Annals of Intensive Care·Faheem W GuirgisFrederick A Moore
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri
Aug 11, 2021·Current Opinion in Lipidology·Grant BarkerSrinivasa Reddy
Sep 19, 2021·Critical Care : the Official Journal of the Critical Care Forum·Faheem W GuirgisSrinivasa T Reddy