HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock

PloS One
Faheem W GuirgisFrederick A Moore

Abstract

High density lipoprotein (HDL) is important for defense against sepsis but becomes dysfunctional (Dys-HDL) during inflammation. We hypothesize that Dys-HDL correlates with organ dysfunction (sequential organ failure assessment (SOFA) score) early sepsis. A prospective cohort study of adult ED sepsis patients enrolled within 24 hours. Eighty eight patients were analyzed. Dys-HDL (expressed as HDL inflammatory index (HII)) correlated with SOFA at enrollment (r = 0.23, p = 0.024) and at 48 hours (r = 0.24, p = 0.026) but HII change over the first 48 hours did not correlate with change in SOFA (r = 0.06, p = 0.56). Enrollment HII was significantly different in patients with most severe organ failure (2.31, IQR 1.33-5.2) compared to less severe organ failure (1.81, IQR 1.23-2.64, p = 0.043). Change in HII over 48 hours was significantly different for in-hospital non-survivors (-0.45, IQR-2.6, -0.14 p = 0.015) and for 28-day non-survivors (-1.12, IQR -1.52, 0.12, p = 0.044). In a multivariable linear regression equation (R2 = 0.13), for each unit HII increase, 48-hour SOFA increased by 0.72 (p = 0.009). HII correlated with SOFA and predicted 48-hour SOFA score in early sepsis. Future studies are needed to delineate potential mechanis...Continue Reading

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Citations

Jan 17, 2019·Current Opinion in Lipidology·Mark TrinderLiam R Brunham
Oct 3, 2019·Current Opinion in Lipidology·Fabrizia BonacinaGiuseppe D Norata
Jan 5, 2021·Journal of the American College of Emergency Physicians Open·Faheem W GuirgisFrederick Moore
Nov 10, 2020·Journal of Psoriasis and Psoriatic Arthritis·Alexander V SorokinNehal N Mehta
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra ZeljkovicBratislav Trifunovic
May 22, 2021·Annals of Intensive Care·Faheem W GuirgisFrederick A Moore
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri
Aug 11, 2021·Current Opinion in Lipidology·Grant BarkerSrinivasa Reddy
Sep 19, 2021·Critical Care : the Official Journal of the Critical Care Forum·Faheem W GuirgisSrinivasa T Reddy

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