Feb 23, 2011

HDL: the yin-yang of cardiovascular disease

Arquivos brasileiros de endocrinologia e metabologia
Camila Canteiro LeançaEder C R Quintão

Abstract

Epidemiological studies demonstrate an inverse correlation between plasma HDL-cholesterol (HDL-C) concentration and incidence of cardiovascular disease (CVD). The antiatherogenic role of HDL has been attributed to its anti-inflammatory, antithrombotic and antioxidant properties, besides its participation in the reverse cholesterol transport (RCT), whereby cholesterol from peripheral tissues (including macrophages of the arterial intima) is delivered to the liver for excretion in bile. Due to these actions, HDL-C has evolved as an attractive target for prevention of CVD. However, the failure of torcetrapib, drug that substantially increases HDL-C levels, in preventing CVD and data from studies with animal models and with carriers of monogenic disorders affecting HDL-C levels in humans provide conflicting data about HDL being antiatherogenic. This review addresses the current state of knowledge regarding HDL based on these recent controversies.

  • References41
  • Citations3

Citations

Mentioned in this Paper

Yin-Yang
Anti-Inflammatory Agents
Quinolines
Reverse Cholesterol Transport
Antioxidants
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Cardiovascular Diseases
Body Excretions
Excretory Function
High Density Lipoprotein Cholesterol

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